NBEA Antibody

Datasheet

Code	CSB-PA059985
Size	US$166
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Image	The image on the left is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using CSB-PA059985(NBEA Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200) The image on the left is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using CSB-PA059985(NBEA Antibody) at dilution 1/60, on the right is treated with synthetic peptide. (Original magnification: ×200)
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Product Details
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Target Background

Product Details

Uniprot No.

Q8NFP9

Target Names

NBEA

Alternative Names

BCL8B antibody; FLJ10197 antibody; KIAA1544 antibody; Lysosomal trafficking regulator 2 antibody; Lysosomal-trafficking regulator 2 antibody; LYST2 antibody; NBEA antibody; NBEA_HUMAN antibody; Neurobeachin antibody; Protein BCL8B antibody; Protein neurobeachin antibody; RP11-270C18.1 antibody

Raised in

Rabbit

Species Reactivity

Human,Mouse

Immunogen

Synthetic peptide of Human NBEA

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

Isotype

IgG

Purification Method

Antigen affinity purification

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

-20°C, pH7.4 PBS, 0.05% NaN3, 40% Glycerol

Form

Liquid

Tested Applications

ELISA,IHC

Recommended Dilution

Application	Recommended Dilution
ELISA	1:1000-1:5000
IHC	1:25-1:100

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

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Target Background

Function

Binds to type II regulatory subunits of protein kinase A and anchors/targets them to the membrane. May anchor the kinase to cytoskeletal and/or organelle-associated proteins.

Gene References into Functions

NBEA encodes neurobeachin: we found no evidence of association in data from the GWAS migraine meta-analysis consortium (n=118,710 participants) suggesting that the association might be specific to migraine co-morbid with bipolar disorder. PMID: 25451450
Data indicate that the PVT1-NBEA and the PVT1-WWOX chimeric genes were associated with the expression of abnormal NBEA and WWOX. PMID: 22869583
Synapse associated protein 102 (SAP102) binds the C-terminal part of the scaffolding protein neurobeachin. PMID: 22745750
data obtained in mice and humans suggest that variation of Nbea abundance or activity critically affects body weight, presumably by influencing the activity of feeding-related neural circuits PMID: 22438821
Structural analysis and biochemical studies show that the PH and BEACH domains have strong interactions, suggesting they may function as a single unit. PMID: 12234919
neurobeachin encoding gene is disrupted in a patient with a de novo translocation t(5;13) (q12.1;q13.2), idiopathic autism, and no family history of autism PMID: 12746398
The NBEA gene at 13q13, and its expression are frequently disrupted in MM. PMID: 19135901

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Subcellular Location

Cytoplasm. Membrane; Peripheral membrane protein.

Protein Families

WD repeat neurobeachin family

Tissue Specificity

Predominant in many brain structures. Also expressed at medium levels in spleen, thymus, prostate, testis and ovary. Low level expression is seen in heart, kidney, pancreas, skeletal muscle and intestine.

Database Links

HGNC: 7648

OMIM: 604889

KEGG: hsa:26960

STRING: 9606.ENSP00000383295

UniGene: Hs.491172

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Protein Service

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

Call us

301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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