NEUROD2 Antibody

Datasheet

Code	CSB-PA614900LA01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NEUROD2 Polyclonal antibody

Uniprot No.

Q15784

Target Names

NEUROD2

Alternative Names

bHLHa1 antibody; class A basic helix loop helix protein 1 antibody; Class A basic helix-loop-helix protein 1 antibody; NDF2_HUMAN antibody; NDR2 antibody; NDRF antibody; neuroD related factor antibody; NeuroD-related factor antibody; NeuroD2 antibody; neurogenic basic helix loop helix protein antibody; neurogenic differentiation 2 antibody; Neurogenic differentiation factor 2 antibody; neuronal differentiation 2 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Neurogenic differentiation factor 2 protein (254-339AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The NEUROD2 Antibody (Product code: CSB-PA614900LA01HU) is Non-conjugated. For NEUROD2 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA614900LB01HU	NEUROD2 Antibody, HRP conjugated	ELISA
FITC	CSB-PA614900LC01HU	NEUROD2 Antibody, FITC conjugated
Biotin	CSB-PA614900LD01HU	NEUROD2 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Transcriptional regulator implicated in neuronal determination. Mediates calcium-dependent transcription activation by binding to E box-containing promoter. Critical factor essential for the repression of the genetic program for neuronal differentiation; prevents the formation of synaptic vesicle clustering at active zone to the presynaptic membrane in postmitotic neurons. Induces transcription of ZEB1, which in turn represses neuronal differentiation by down-regulating REST expression. Plays a role in the establishment and maturation of thalamocortical connections; involved in the segregation of thalamic afferents into distinct barrel domains within layer VI of the somatosensory cortex. Involved in the development of the cerebellar and hippocampal granular neurons, neurons in the basolateral nucleus of amygdala and the hypothalamic-pituitary axis. Associates with chromatin to the DPYSL3 E box-containing promoter.

Gene References into Functions

Our findings suggest that the NEUROD2 gene could play a role in the pathophysiology of neurocognitive dysfunctions as well as in the change of cognitive symptoms under antipsychotic treatment in schizophrenia and schizoaffective disorder. PMID: 28470106
Downregulation of NEUROD2 is associated with neurodevelopmental defects in trisomies 18. PMID: 22752091
The results of this study did not provide evidence for an involvement of NEUROD2 polymorphisms in the pathophysiology of alcohol dependence. PMID: 20880594
Lower neuroD2 mRNA levels was found in opiate-dependent individuals in the cortex and hippocampus. PMID: 16607387

Subcellular Location

Nucleus.

Database Links

HGNC: 7763

OMIM: 601725

KEGG: hsa:4761

STRING: 9606.ENSP00000306754

UniGene: Hs.322431

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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