NFAM1 Antibody

Code CSB-PA850874LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA850874LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NFAM1 Polyclonal antibody
Uniprot No.
Target Names
NFAM1
Alternative Names
NFAM1 antibody; CNAIPNFAT activation molecule 1 antibody; Calcineurin/NFAT-activating ITAM-containing protein antibody; NFAT-activating protein with ITAM motif 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human NFAT activation molecule 1 protein (186-270AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The NFAM1 Antibody (Product code: CSB-PA850874LA01HU) is Non-conjugated. For NFAM1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA850874LB01HU NFAM1 Antibody, HRP conjugated ELISA
FITC CSB-PA850874LC01HU NFAM1 Antibody, FITC conjugated
Biotin CSB-PA850874LD01HU NFAM1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
May function in immune system as a receptor which activates via the calcineurin/NFAT-signaling pathway the downstream cytokine gene promoters. Activates the transcription of IL-13 and TNF-alpha promoters. May be involved in the regulation of B-cell, but not T-cell, development. Overexpression activates downstream effectors without ligand binding or antibody cross-linking.
Gene References into Functions
  1. CNAIP is a ITAM-containing protein that activates the calcineurin/NFAT-signaling pathway and the downstream cytokine gene promoters PMID: 12615919
  2. Our results demonstrate NFAT expression and activation in native human vessels and point out A-285222 as a powerful pharmacological blocker of NFAT signaling in the vasculature. PMID: 17079331
  3. NFAT plays a role in SV40 infection via transcriptional control of Simian Virus 40. PMID: 18031784
  4. Our findings define a pathway involving CD28 binding to Grb-2 and its co-operativity with Vav1 in the regulation of T-cell co-stimulation. PMID: 18295596
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Tissue Specificity
Highly expressed in neutrophils, primary monocytes, mast cells, monocytic cell lines and lymphocytes. Also expressed in spleen B and T-cells, and lung. Expressed at low level in non-immune tissue.
Database Links

HGNC: 29872

OMIM: 608740

KEGG: hsa:150372

STRING: 9606.ENSP00000333680

UniGene: Hs.436677

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