NFIL3 Antibody

1. data provide evidence that E4BP4 attenuates RASSF8-mediated anti-proliferation and apoptosis, shedding mechanistic insights into RASSF8 down-regulation in breast cancers. PMID: 29467226
2. Here we review the regulatory mechanisms of E4BP4 engaging in not only the biological function but also the development of immune-mediated diseases, paving the way for future therapies PMID: 28365317
3. glucocorticoid-mediated transactivating pathway may support eosinophil viability in IL-5-stimulated cells through synergistic upregulation of NFIL3 PMID: 26880402
4. E4BP4 and BIM regulation correlated with that of RCAN1-1. A putative GRE and four EBPREs were identified within 1500bp upstream from the transcription start site of RCAN1-1 PMID: 26102033
5. Results conclude that the transcriptional repressor E4BP4 plays a role in repressing epigenetically regulated SOSTDC1 expression in breast cancer cells, which can be reverted by E4BP4 silencing. PMID: 25338303
6. NFIL3 plays a neuroprotective role in neurons and constitutes a potential therapeutic target for neurodegeneration. PMID: 24280221
7. Data indicate that E4BP4 can inhibit CD40L expression through epigenetic modifications in the promoter region of CD40L. PMID: 23340290
8. NFIL3 alters cancer cell behavior and FOXO function by acting on chromatin to restrict the menu of FOXO target genes PMID: 23630076
9. The clock-regulated and immune system modulator transcription factor E4BP4/ NFIL3 likely regulates the expression of both appb in zebrafish and APP in humans. PMID: 22947103
10. G9a mediates E4BP4-dependent suppression of hepatic Fgf21 by enhancing histone methylation (H3K9me2) of the Fgf21 promoter PMID: 23283977
11. Conclude that E4BP4 plays as a survival factor in heart and E4BP4 is essential for proper embryonic heart development. PMID: 20186462
12. This report demonstrates that GC-mediated upregulation of the bZIP transcriptional repressor gene, E4BP4, is dependent on [Ca2+]i levels, and correlates with GC-evoked apoptosis of GC-sensitive CEM-C7-14 cells. PMID: 16630563
13. E4BP4 has a role as osteoblast transcriptional repressor in inhibiting both Runx2 and Osterix in myeloma bone disease PMID: 18829486
14. Identification of adjacent binding sites for the YY1 and E4BP4 transcription factors in the PrP (Prion) gene promoter. PMID: 19129193

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HGNC: 7787

OMIM: 605327

KEGG: hsa:4783

STRING: 9606.ENSP00000297689

UniGene: Hs.79334