NFKBIL1 Antibody

Datasheet
Code CSB-PA887001LA01HU
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Size US$299
Uniprot No. Q9UBC1
Image
  • IHC image of CSB-PA887001LA01HU diluted at 1:600 and staining in paraffin-embedded human brain tissue performed on a Leica BondTM system. After dewaxing and hydration, antigen retrieval was mediated by high pressure in a citrate buffer (pH 6.0). Section was blocked with 10% normal goat serum 30min at RT. Then primary antibody (1% BSA) was incubated at 4°C overnight. The primary is detected by a biotinylated secondary antibody and visualized using an HRP conjugated SP system.

Immunogen Recombinant Human NF-kappa-B inhibitor-like protein 1 protein (185-312AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA, IHC; Recommended dilution: IHC:1:500-1:1000
Relevance Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli.
Form Liquid
Conjugate Non-conjugated
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias NF-kappa-B inhibitor-like protein 1 (Inhibitor of kappa B-like protein) (I-kappa-B-like protein) (IkappaBL) (Nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor-like 1), NFKBIL1, IKBL
Immunogen Species Human
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Research Area Signal Transduction
Target Names NFKBIL1
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Involved in the regulation of innate immune response. Acts as negative regulator of Toll-like receptor and interferon-regulatory factor (IRF) signaling pathways. Contributes to the negative regulation of transcriptional activation of NF-kappa-B target genes in response to endogenous proinflammatory stimuli.
Involvement in disease Rheumatoid arthritis (RA)
Subcellular Location Nucleus
Tissue Specificity Detected in different cell types including monocytes, T-cells, B-cells and hepatocytes.
Database Links

HGNC: 7800

OMIM: 180300

KEGG: hsa:4795

STRING: 9606.ENSP00000365318

UniGene: Hs.2764

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