NFKBIL1 Antibody

1. genetic association studies in a population of black women in South Africa: Data suggest that an SNP in NFKBIL1 (rs2071592) is associated with iron status/iron-deficiency anemia in the population studied. PMID: 25809685
2. These observations suggest a functional involvement of IkappaBL in the regulation of alternative splicing in both human and viral genes, which is a novel link of HLA locus to the regulation of immunity and infection in humans. PMID: 23953137
3. an association was noted between IKBL-62T and idiopathic inflammatory myopathy, with increased risk noted in anti-Jo-1- and -PM-Scl antibody-positive patients; the IKBL-62T association is dependent on TNF-308A and HLA-B*08, due to strong shared linkage disequilibrium between these alleles PMID: 22210660
4. results do not provide evidence for the association between the -62A/T NFKBIL1 polymorphism and obsessive-compulsive disorder in this Brazilian sample. PMID: 19578685
5. Results of the present study do not provide evidence for the association between the NFKBIL1 exon 4 polymorphism and MS predisposition in the investigated Polish population. PMID: 20568399
6. The DPB1 gene controlled the severity of the vascular lesion, whereas the IKBL gene (NFKBIL1) was associated with a relatively mild phenotype. PMID: 19165231
7. identifed the second rheumatoid arthritis -susceptibility locus within the HLA region, as the T allele of SNP 96452 (T/A), in the promoter region (position -62) of the I kappa BL gene (P=.0062) PMID: 12509789
8. study shows that the estimated haplotype IkBL -421 8T/-62 T tends to be associated with susceptibility to rheumatoid arthritis in Taiwan PMID: 16644022
9. no association between polymorphisms and hypertension, myocardial infarct and angina in Irish PMID: 17485095
10. Minor homozygous genotypes of polymorphisms in NFKBIL1 were associated with moderately protective effects against myocardial infarction. PMID: 17517687
11. The IKBL locus itself or another critical gene in this region may confer susceptibility to the development of chronic Chagas cardiomyopathy. PMID: 17544510
12. IL1RN VNTR and the IKBL + 738T > C gene polymorphisms are not risk factors for myocardial infarct in Caucasians with type 2 diabetes PMID: 17847930
13. A potential role for NFkBL1 in the pathogenesis of rheumatoid arthritis and in mRNA processing or the regulation of translation. PMID: 17855452
14. IkappaBL allele polymorphisms influences risk of acquiring systemic lupus erythematosus and Sjogren's syndrome. PMID: 18295675

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HGNC: 7800

OMIM: 180300

KEGG: hsa:4795

STRING: 9606.ENSP00000365318

UniGene: Hs.2764