NKX2-8 Antibody, HRP conjugated

Datasheet

Code	CSB-PA015847LB01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) NKX2-8 Polyclonal antibody

Uniprot No.

O15522

Target Names

NKX2-8

Alternative Names

Homeobox protein NK 2 homolog H antibody; Homeobox protein NK-2 homolog H antibody; Homeobox protein Nkx 2.8 antibody; Homeobox protein Nkx-2.8 antibody; NK 2 homolog 8 antibody; NK 2 homolog H antibody; NK2 homeobox 8 antibody; NK2 transcription factor related; locus 8 antibody; Nkx2 9 antibody; Nkx2-8 antibody; NKX2.8 antibody; NKX28_HUMAN antibody; NKX2G antibody; NKX2H antibody; OTTHUMP00000027959 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Homeobox protein Nkx-2.8 protein (1-160AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Gene References into Functions

Results show that Nkx2-8 functions as a tumor suppressor in esophageal squamous cell carcinoma (ESCC), the downregulation of which contributes to NF-kappaB P65 activation and ESCC angiogenesis. PMID: 23604637
overexpression of Nkx2.8 resulted in downregulation of p-FOXO3a and inhibition of MEK/ERK pathway activity. silencing Nkx2.8 led to upregulation of p-FOXO3a and increase of MEK/ERK pathway activity. PMID: 22223847
Most tumors have low expression of Nkx2-8, and its expression can inhibit growth of some lung cancer cells. PMID: 21148747
A murine Nkx2.8 was isolated from the Hepal-6 cell line and showed oligonucleotide binding competitive with fetoprotein transcription factor. PMID: 12167706
Coactivation of the TTF-1 and NKX2-8 pathways identified a cluster of lung cancer patients with poor survival and were shown to exhibit resistance to cisplatin PMID: 19279207

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Subcellular Location

Nucleus.

Protein Families

NK-2 homeobox family

Database Links

HGNC: 16364

OMIM: 603245

KEGG: hsa:26257

STRING: 9606.ENSP00000258829

UniGene: Hs.234763

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Service

Phage Display Service

Antibody Service

Protein Service

Gene Synthesis Service

Oligo Synthesis Service

Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

[email protected]

Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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