NKX3-1 Antibody

1. The tumour suppressors FOXP1 and NKX3.1, strongly implicated in PCa development, were identified as key transcription factors regulating TPbeta expression through Prm3 in both PCa cell lines. PMID: 28890397
2. NKX3.1 has potential utility as a prostate specific marker in the differential diagnostic distinction between nephrogenic adenoma and prostatic adenocarcinoma. PMID: 28581204
3. Prostate cancer patients with low NKX3.1 expression are optimal candidates for intervention with 5alpha-reductase inhibitors as an adjunct to active surveillance. PMID: 28385453
4. Low NKX3.1 expression is associated with hepatocellular carcinoma. PMID: 28972178
5. During prostate cancer initiation, Nkx3.1 expression is frequently lost in both humans and mouse models. Data, including data from studies using cells from transgenic mice, suggest that androgens activate Nkx3.1 transcription via androgen receptor binding to 11-kb region in both normal luminal cells and castration-resistant prostatic neoplasm cells via androgen response elements in Nkx3.1 3prime untranslated region. PMID: 28679531
6. With deletion mutation analysis, plasmid construction, EMSA and oligonucleotide decoy technique, two Sp1-elements which located between +29 to +43 and -60 to -46 of NKX3.1 gene were identified and proven to be functional elements. PMID: 19263243
7. The androgen-regulated homeodomain transcription factor NKX3.1 plays roles in early prostate development and functions as a prostate-specific tumor suppressor. PMID: 26841725
8. the association between the down-regulation of PTEN and NKX3.1 genes contributed to prostate tumorigenesis. PMID: 26689514
9. NKX3.1 and DYRK1B were shown to interact via the DYRK1B kinase domain. In vitro kinase assay showed that DYRK1B phosphorylated NKX3.1 at serine 185, a residue critical for NKX3.1 steady-state turnover. PMID: 25777618
10. An NKX3.1 binding site polymorphism in the l-plastin promoter leads to differential gene expression in human prostate cancer PMID: 26148677
11. Analysis of prostate cancer tissues showed that the presence of a TMPRSS2-ERG rearrangement was highly correlated with lower levels of NKX3.1 expression consistent with the role of NKX3.1 as a suppressor of the pathogenic gene rearrangement. PMID: 25977336
12. NKX3.1 expression mediate beta-catenin and E-cadherin association and cell migration in prostate cells. PMID: 25360740
13. Our results indicate that variation in NKX3.1 expression combined with selenium or vitamin E treatment modifies the risk of prostate cancer. PMID: 24894197
14. Id4 regulates NKX3.1, Sox9 and PTEN. PMID: 23786676
15. NKX3.1 labelling is limited to estrogen/progesterone/androgen receptor-positive breast carcinomas. PMID: 24996432
16. These observations imply that the frequently noted loss-of-function of NKX3.1 cooperates with the activation of TMPRSS2-ERG fusions in prostate tumorigenesis. PMID: 24418414
17. NKX3.1 may enhance DNA integrity in prostate stem cells and may help to explain how cells differ in their sensitivity to DNA damage. PMID: 23890999
18. Androgens and NKX3.1 expression regulate the progression of the cell cycle and concurrently activate the DNA damage response. PMID: 24434284
19. Loci at 8q24 and 8q21 could influence susceptibility to prostate cancer in the northern Chinese population PMID: 24779299
20. multiple NKX3.1 binding sites were found in the RAMP1 locus in human prostate cancer cells and in the normal mouse prostate. PMID: 23867798
21. NKX3-1 is a tumor suppressor gene through direct regulation of the cell cycle and growth/survival pathways. PMID: 23836514
22. Pim-1-mediated NKX3.1 stabilization may be important in maintaining normal cellular homeostasis in normal prostate epithelial cells, and may maintain basal NKX3.1 protein levels in prostate cancer cells. PMID: 23129228
23. Transcriptional activation of prostate specific homeobox gene NKX3-1 in subsets of T-cell lymphoblastic leukemia (T-ALL). PMID: 22848398
24. PDLIM5 (rs17021918,T), SLC22A3 (rs9364554,C) and NKX3-1 (rs1512268,A) SNPs might not be associated with prostate cancer in Chinese men. PMID: 22741436
25. Proline-mediated proteasomal degradation of the prostate-specific tumor suppressor NKX3.1. PMID: 22910912
26. NKX3.1 inhibits IGF-1R expression and its signalling pathway in human prostatic carcinoma PC3 cells. PMID: 22179513
27. loss of NKX3-1 may be a potential biomarker for occult lymph node metastasis and poor prognosis in oral squamous cell carcinoma. PMID: 22344708
28. NKX3-1 and androgen receptor directly regulate each other in a feed-forward regulatory loop. PMID: 22083957
29. androgen regulated NKX3.1 maintains an active DNA damage response at the intra S progression and contributes to the chemotherapeutic resistance of prostate cancer cells to DNA damaging compounds. PMID: 21945437
30. Copy number gain of the MIR151 gene and/or loss of the NKX3-1 gene in the primary tumor may indicate the presence of metastatic prostate cancer. PMID: 21456068
31. results suggest that functional variant rs11781886 in 5'-UTR of NKX3.1 can affect its transcription by altering the binding affinity of a transcriptional factor Sp1, and might result in PC susceptibility by lowering expression of NKX3.1 in the prostate PMID: 20716579
32. ETS1 upregulation of NKX3.1 expression in LNCaP cells is mediated in part via its interaction with an EBS located in the NKX3.1 5' proximal promoter. PMID: 20842667
33. in human TAL1-expressing T-ALL cell lines, TAL1 directly activates NKX3.1 PMID: 20855495
34. Nkx3.1 has a role in bacterial prostatitis and its progression to inflammation and neoplasia PMID: 20363913
35. The prostate-specific tumor suppressor gene Nkx3.1 was controlled by ERG and ESE3 both directly and through induction of EZH2. PMID: 20479932
36. The addition of NKX3.1 protein staining to a panel of markers, if applied in the appropriate clinicopathologic context, may add diagnostic value in the diagnosis of metastatic lesions of unknown primary origin. PMID: 20588175
37. NKX3.1 might exert its function by regulating the expression of relative genes in prostate development and carcinogenesis. PMID: 19462257
38. NKX3.1 activates cellular response to DNA damage PMID: 20395202
39. Androgen regulation of the prostatic tumour suppressor NKX3.1 is mediated by its 3' untranslated region PMID: 19886863
40. NKX-3.1 interacts with prostate-derived Ets factor and regulates the activity of the PSA promoter. PMID: 11809674
41. smooth muscle gamma actin gene activity in prostate epithelia is due, in part, to the androgen-dependent expression of Nkx 3.1 PMID: 12450213
42. Expression of NKX3.1 is highly restricted and is found primarily in benign and malignant prostatic epithelial cells and also in normal testis and lobular carcinoma of the breast. PMID: 12661036
43. NKX3.1 is essential for normal testis function and that its loss of expression is highly associated with the invasive phenotype of testicular germ cell tumors. PMID: 14633588
44. Nkx3.1 homeobox gene has roles in prostate organogenesis and carcinogenesis (review) PMID: 14648854
45. NKX3.1 does not function as a typical tumor suppressor protein in prostate cancer but it may still have important regulatory roles during prostate cancer progression PMID: 15311057
46. identified novel protein-protein interaction domains within NKX-3.1 and PDEF that operate in concert with their respective DNA binding domains to mediate functional interactions between these growth regulatory transcription factors PMID: 15523673
47. Down-regulation of NKX3.1 expression is not caused by promoter hypermethylation in testicular germ cell tumors and prostate carcinomas. PMID: 15691383
48. Even in the presence of allelic loss, NKX3.1 expression is reduced over a wide range in prostate cancer. PMID: 15734999
49. We found that the 20 bp inhibitory decoy could enhance NKX3.1 promoter activity, and RT-PCR and Western blot analysis revealed that NKX3.1 expression was up-regulated effectively by the transfection with the 20 bp inhibitory decoy. PMID: 15880262
50. Nkx3.1 negatively regulates Sp-mediated transcription via the tethering of histone deacetylases and/or by inhibiting the association of Sp proteins with co-activators. PMID: 16201967

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HGNC: 7838

OMIM: 602041

KEGG: hsa:4824

STRING: 9606.ENSP00000370253

UniGene: Hs.55999