NLGN4X Antibody, HRP conjugated

Code CSB-PA843131LB01HU
Size US$166
Order now
Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NLGN4X Polyclonal antibody
Uniprot No.
Target Names
NLGN4X
Alternative Names
ASPGX2 antibody; AUTSX2 antibody; HLNX antibody; HNL4X antibody; HNLX antibody; KIAA1260 antibody; neuroligin 4, X-linked antibody; Neuroligin X antibody; Neuroligin-4 antibody; NL4 antibody; NLGN antibody; NLGN4 antibody; NLGN4X antibody; NLGNX_HUMAN antibody; OTTHUMP00000022863 antibody; OTTHUMP00000022864 antibody; OTTHUMP00000022865 antibody; X-linked antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Neuroligin-4, X-linked protein (383-494AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Putative neuronal cell surface protein involved in cell-cell-interactions.
Gene References into Functions
  1. NLGN4X might represent novel biomarkers and therapeutic targets for breast cancer. Inhibition of NLGN4X may be a new target for the prevention and treatment of breast cancer PMID: 29244827
  2. Noncoding polymorphisms on NLGN4X may be associated to autism suggesting the key role of NLGN4X in autism pathophysiology and in its male prevalence. PMID: 27782075
  3. Endogenous NLGN4X is intensely phosphorylated on T707 upon PKC stimulation in human neurons. PMID: 25675530
  4. In vitro models show NLGN4X knockdown directly impacts neurodevelopmental process during the formation of neurons and their connections. PMID: 23710042
  5. Five genes have been directly disrupted in Tourette Syndrome by independent genomic rearrangements and copy number variations with unique breakpoints. PMID: 22948383
  6. The autism-associated DeltaE4 mutation in NLGN4 compromises the ability of NLGN4 to localize correctly to the cell surface when overexpressed and to induce synaptic differentiation. PMID: 21278334
  7. results indicate that the genetic variants located in NLGN4 can affect the cognitive abilities of boys. PMID: 20714171
  8. Results suggest that unique conformational reshaping of the neuroligin 4 surface is required to permit neurexin 1beta association. PMID: 20543817
  9. finding further contributes to consideration of neuroligins as probable candidate genes for future molecular genetic studies, suggesting that a defect of synaptogenesis may predispose to autism PMID: 19645625
  10. Scanning and sequencing of 2.5Mb of the NLGN4 genes reveals an association of NLGN4 structural variants at highly conserved amino acids with an estimated attributable risk for autism of about 3% in the cohorts studies. PMID: 15622415
  11. Data indicate that coding mutations in neuroligin 4 are very rarely associated to autism spectrum disorders. PMID: 16508939
  12. Splice variants of the NLGN4 gene are associated with autism. PMID: 16648374
  13. Syntrophin-gamma2 (SNTG2) is a de novo binding partner of X-linked neuroligin 4, which correlates with autism-related mutations. PMID: 17292328
  14. NLGN4 mutations can be associated with a wide spectrum of neuropsychiatric conditions and that carriers may be affected with milder symptoms PMID: 18231125
  15. The results suggest a positive association between the genetic variants of the NLGN4 and NSMR in the Chinese children from Qinba Mountains Region. PMID: 19125102
  16. This study indicated that the phenotypic spectrum of NLGN4X mutations and overexpressed NLGN4X transcript is associated with autism and nonsyndromic mental profound mental retardation. PMID: 19545860
  17. NLGN4X gene is associated with autistic traits, empathy, and Asperger syndrome. PMID: 19598235
  18. Two brothers with classical autism spectrum disorder carry a single amino-acid substitution in neuroligin 4 (Arg87Trp). The substitution is absent from the brothers' asymptomatic parents, suggesting that it arose in the maternal germ line. PMID: 19726642

Show More

Hide All

Involvement in disease
Autism, X-linked 2 (AUTSX2); Asperger syndrome, X-linked, 2 (ASPGX2)
Subcellular Location
Cell membrane; Single-pass type I membrane protein. Cell junction, synapse, postsynaptic density membrane.
Protein Families
Type-B carboxylesterase/lipase family
Tissue Specificity
Expressed at highest levels in heart. Expressed at lower levels in liver, skeletal muscle and pancreas and at very low levels in brain.
Database Links

HGNC: 14287

OMIM: 300427

KEGG: hsa:57502

STRING: 9606.ENSP00000275857

UniGene: Hs.21107

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*