NSUN2 Antibody, Biotin conjugated

1. Upregulation of NSUN2 expression is associated with ovarian cancer. PMID: 28829218
2. Patients with high NSUN2 levels had approximately 22 months shorter overall survival, and had a higher mortality risk than those with low one (p-trend = 0.020). PMID: 29775108
3. Dysregulation of ALYREF-mediated mRNA export upon NSUN2 depletion could be restored by reconstitution of wild-type but not methyltransferase-defective NSUN2. PMID: 28418038
4. methylation at m6A by METTL3/METTL14 facilitates the methylation of m5C by NSUN2, and vice versa. NSUN2-mediated m5C and METTL3/METTL14-mediated m6A methylation synergistically enhance p21 expression at the translational level PMID: 28247949
5. Findings indicate the critical impact of RNA methyltransferase NSUN2-mediated mRNA methylation in promoting premature senescence. PMID: 26992231
6. Our findings provide a unique insight into the roles and effects of NSUN2 overexpression in breast cancer cells PMID: 27447970
7. findings point to YB-1 and NSUN2 as possible mediators of the process of transfer of specific mRNAs into exosomes, allowing us to speculate on an involvement of these proteins in the mRNA sorting via the recognition of the above motifs PMID: 28341602
8. These findings indicate that NSun2-mediated mRNA methylation regulates p27 and CDK1 levels during replicative senescence. PMID: 26687548
9. A novel homozygous variant c.1020delA in NSUN2 gene segregated in an autosomal recessive mode in the family of a child with intellectual disability. It causes a frameshift and premature stop codon, decreasing mRNA levels. PMID: 26055038
10. By methylating the CDK1 mRNA at the 3'UTR, NSun2 enhances the translation of CDK1, thereby influencing entry into and the progression of the cell division cycle. PMID: 26391950
11. tRNA modifying enzymes, NSUN2 and METTL1, determine sensitivity to 5-fluorouracil in HeLa cells PMID: 25233213
12. Report frequencies of short tandem repeat markers linked to TUSC3 (MRT7) or NSUN2 (MRT5) genes used for homozygosity mapping of recessive intellectual disability. PMID: 26427135
13. Results show that NSun2 methylates primary (pri-miR-125b), precursor (pre-miR-125b), and mature microRNA 125b (miR-125b) in vitro and in vivo. PMID: 25047833
14. In conclusion, failure in NSun2-mediated tRNA methylation contributes to human diseases via stress-induced RNA cleavage. PMID: 25063673
15. Impaired processing of vault ncRNA may contribute to the etiology of NSun2-deficiency human disorders. PMID: 23871666
16. Enrolled a multiplex consanguineous family from the United Arab Emirates with many key clinical features of Dubowitz syndrome. Identified a homozygous splice mutation in the NSUN2 gene, encoding a conserved RNA methyltransferase. PMID: 22577224
17. findings show that NSun2, a transfer RNA methyltransferase, inhibits the turnover of p16(INK4) mRNA; conclude that NSun2-mediated methylation of the p16 3'UTR is a novel mechanism to stabilize p16 mRNA PMID: 22395603
18. Increased gene copy number and high protein expression of NSUN2 is associated with cancers. PMID: 22136356
19. A deficiency in NSUN2 function causes intellectual disability in individuals homozygous for these mutations. PMID: 22541559
20. The substitution of glycine to arginine at position 679 impairs the proper cellular localization of NSUN2 to the nucleolus. This mutation causes autosomal-recessive intellectual disability. PMID: 22541562
21. was extensive copy number gain, and increased mRNA and protein levels, of Misu in approximately one third of breast cancer cell lines and primary tumours examined, irrespective of tumour subtype PMID: 19740597
22. First report showing intron-dependent methylation of human pre-tRNA Leu(CAA) and identification of human gene encoding tRNA methylase(Trm4) responsible for this reaction. PMID: 17071714
23. These results indicate that Aurora-B participates to regulate the assembly of nucleolar RNA-processing machinery and the RNA methyltransferase activity of NSUN2 via phosphorylation at Ser139 during mitosis. PMID: 17215513
24. These results suggest a novel mechanism by which c-Myc promotes proliferation by stabilizing the mitotic spindle in fast-dividing cells via Misu and NuSAP. PMID: 19596847

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HGNC: 25994

OMIM: 610916

KEGG: hsa:54888

STRING: 9606.ENSP00000264670

UniGene: Hs.481526