NSUN4 Antibody, HRP conjugated

Code CSB-PA850270LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) NSUN4 Polyclonal antibody
Uniprot No.
Target Names
NSUN4
Alternative Names
5 methylcytosine rRNA methyltransferase NSUN4 antibody; EC=2.1.1.- antibody; NOL1/NOP2/Sun domain family member 4 antibody; NOL1/NOP2/Sun domain family, member 4 antibody; NOP2/Sun domain family, member 4 antibody; Nsun4 antibody; NSUN4_HUMAN antibody; Putative methyltransferase NSUN4 antibody; RP4-603I14.2 antibody; Shtap antibody; Sperm head and tail associated protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human 5-methylcytosine rRNA methyltransferase NSUN4 protein (26-284AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Involved in mitochondrial ribosome assembly. 5-methylcytosine rRNA methyltransferase that probably is involved in mitochondrial ribosome small subunit (SSU) maturation by methylation of mitochondrial 12S rRNA; the function is independent of MTERFD2/MTERF4 and assembled mitochondrial ribosome large subunit (LSU). Targeted to LSU by MTERFD2/MTERF4 and probably is involved in a final step in ribosome biogenesis to ensure that SSU and LSU are assembled. In vitro can methylate 16S rRNA of the LSU; the methylation is enhanced by MTERFD/MTERF4.
Gene References into Functions
  1. It involves in epigenetic changes during the progression of Alzheimer disease pathology. PMID: 24387984
  2. analysis of the 3D crystal structure of the human MTERF4-NSUN4 complex PMID: 22949673
  3. Observational study of gene-disease association. (HuGE Navigator) PMID: 19086053
Subcellular Location
Mitochondrion.
Protein Families
Class I-like SAM-binding methyltransferase superfamily, RsmB/NOP family
Database Links

HGNC: 31802

OMIM: 615394

KEGG: hsa:387338

STRING: 9606.ENSP00000419740

UniGene: Hs.163424

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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