Nucb2 Antibody, Biotin conjugated

Code CSB-PA884912LD01RA
Size US$166
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Product Details

Full Product Name
Rabbit anti-Rattus norvegicus (Rat) Nucb2 Polyclonal antibody
Uniprot No.
Target Names
Nucb2
Alternative Names
Nucb2 antibody; Nefa antibody; Nucleobindin-2 antibody; DNA-binding protein NEFA antibody; Prepronesfatin) [Cleaved into: Nesfatin-1] antibody
Raised in
Rabbit
Species Reactivity
Rat
Immunogen
Recombinant Rat Nucb2 protein (194-420AA)
Immunogen Species
Rattus norvegicus (Rat)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Calcium-binding protein which may have a role in calcium homeostasis. Acts as a non-receptor guanine nucleotide exchange factor which binds to and activates guanine nucleotide-binding protein (G-protein) alpha subunit GNAI3.; Anorexigenic peptide, seems to play an important role in hypothalamic pathways regulating food intake and energy homeostasis, acting in a leptin-independent manner. May also exert hypertensive roles and modulate blood pressure through directly acting on peripheral arterial resistance.
Gene References into Functions
  1. Statistically significant alterations were detected in the serum and brain levels of these three peptides in both the pentylenetetrazole-induced experimental epilepsy model and acute seizure model. The results of this study may suggest that the increase in FNDC5/irisin levels and nesfatin-1 levels, and the decrease in ghrelin levels may contribute seizure pathophysiology. PMID: 30111257
  2. Activity-based anorexia increased the number of nesfatin-1 immunopositive neurons in the paraventricular nucleus, arcuate nucleus, dorsomedial hypothalamic nucleus, locus coeruleus and in the rostral part of the nucleus of the solitary tract compared to ad libitum fed and activity groups but not to restricted feeding rats. PMID: 28951234
  3. Nesfatin-1 has a role in the reproductive axis of male rat PMID: 27599613
  4. the effects of experimentally induced unilateral Testicular torsion on serum and contralateral testicular tissue ghrelin and NUCB2/nesfatin-1 levels, are reported. PMID: 28838338
  5. Results provide the first evidence that impaired learning and memory in non-alcoholic fatty liver disease rats was, at least partly, associated with increased plasma nesfatin-1 concentration and decreased copine 6 expression in the hippocampus and prefrontal cortex. PMID: 28211103
  6. decrease in nesfatin-1 may contribute to the mechanism governing polycystic ovary syndrome PMID: 28277136
  7. These studies suggest that nesfatin-1 plays an important role in GD-responsive neuronal activity through interactions with CRF signaling pathways in VMH. The hippocampus may participate in the modulation of nesfatin-1-mediated effects in VMH. PMID: 27982684
  8. Results indicate that nesfatin-1-expressing neurones in the brainstem may play an important role in sensing peripheral levels of glucagon-like peptide-1 and leptin in addition to cholecystokinin-8, and also suppress food intake in rats. PMID: 27203571
  9. Data suggest that a single NEFA/nucleobindin 2(NUCB2)/nesfatin-1 neuron in the paraventricular nucleus projects to both the arcuate nucleus and the dorsal vagal complex with axon collateral projection. PMID: 26639940
  10. This study demonstrated that nesfatin-1 requires the activation of the central melanocortin system to increase iBAT thermogenesis and, in turn, overall energy expenditure. PMID: 28851749
  11. upregulation of Pnpla2 expression and activation of ATGL (due to an increase in ABHD5 and decrease in G0S2 levels), as well as a coordinated interplay of these genes with Lipe in mesenteric WAT, contribute, at least in part, to an increase in the concentration of circulating NEFA in rats with reduced fat mass. PMID: 27590244
  12. This study demonstrated that in both the female and male rats, hypothalamic NUCB2 mRNA expression tended to fall throughout development. PMID: 26778702
  13. Nesfatin-1 could be an important factor in the regulation of gustatory function, feeding and perhaps energy homeostasis. PMID: 26522144
  14. Results indicated that acute stress, but not chronic stress, increased the plasma concentration and hypothalamic mRNA expression of NUCB2/nesfatin-1 in rats. PMID: 26297350
  15. Nesfatin-1 signaling in the basom edial amygdala modulates the gastric distension-sensitive neurons discharge and decreases gastric motility via melanocortin 3/4 receptors and modified by the arcuate nucleus PMID: 26144374
  16. Based on the distribution of nesfatin-1 autoradiography, nesfatin-1 is a pleiotropic hormone that is involved in the regulation of several homeostatic functions. PMID: 26801557
  17. the production of NUCB2/nesfatin-1 by the stomach and adipose tissue fluctuates with age to regulate energy homeostasis during different states of development. PMID: 25916958
  18. apelin administration induced an increment of nesfatin-1 in normal rats and plasma levels of nesfatin-1 increase in DOCA-salt hypertension rats. PMID: 25665476
  19. level of nesfatin-1/NUCB2 in the non-catch-up growth group was lower than that in the catch-up growth group during the whole observation period PMID: 25344190
  20. Suggest that gastrointestinal nesfatin-1 may play a significant role in gastric mobility and energy homeostasis. PMID: 24944480
  21. NucB2/Nesfatin-1 might play an important metabolic role during pregnancy and fetal development and its energy balance mediating role should be studied in various physiological and pathological conditions throughout gestation. PMID: 24905431
  22. changes in nesfatin-1/NucB2 mRNA expression were positively correlated with plasma sodium concentration, plasma osmolality, and total protein levels PMID: 24829503
  23. Nesfatin-1 is produced in the periphery and in the brain where it has been demonstrated to regulate appetite, stress hormone secretion, and cardiovascular function. PMID: 24598461
  24. Role of NUCB2/Nesfatin-1 in the hypothalamic control of energy homeostasis. PMID: 24048879
  25. NUCB2/nesfatin-1 is present at the different levels of the pathway involved in the central control of gastric functions. PMID: 24120633
  26. Nesfatin-1 may be associated with irritable bowel syndrome-like visceral hypersensitivity, which may be implicated in brain CRF/CRF1 signaling pathways. PMID: 23801843
  27. Nesfatin-1/NUCB2 is a potential new element of sleep regulation in rats. PMID: 23560056
  28. a functional contribution of the Nesfatin-1 signaling, operated by THA neurons PMID: 23300698
  29. results suggest that a subpopulation of nesfatin neurons belongs to the central network activated by hypoglycemia, and that nesfatin-1 participates in the triggering of physiological and hormonal counter-regulations observed in response to hypoglycemia PMID: 22958274
  30. Nesfatin-1 directly affects myocardial performance, possibly involving pGC-linked NPR-A, the pGC/PKG pathway, and ERK1/2. PMID: 22955491
  31. Locally produced nesfatin-1 may be an important component of the hypothalamic mechanisms controlling fluid and electrolyte homeostasis. PMID: 22375892
  32. our findings indicate that the ICV nesfatin-1 resulted in increased insulin signaling through Akt/AMPK/ TORC2 and provide a potential mechanism for increased insulin sensitivity. PMID: 22688332
  33. NUCB2 may operate directly at the testicular level to link energy homeostasis, puberty onset, and gonadal function PMID: 22334726
  34. structural basis for the properties of Calnuc and NUCB2 binding to Galpha subunits and its regulation by calcium ions. PMID: 21653697
  35. The results are the first to demonstrate that nesfatin-1 modulates blood pressure through directly acting on peripheral arterial resistance. PMID: 22293188
  36. Intracerebroventricular injection of nesfatin-1 stimulates the sympathetic outflow to the kidney and elevated blood pressure in anesthetized rats. PMID: 21451359
  37. Bacterial lipopolysaccharide increases gastric corpus Nucb2 protein concentration. PMID: 21782869
  38. the nesfatin-1-operative oxytocinergic signaling in the hypothalamic paraventricular nucleus triggers leptin-independent melanocortin-mediated anorexia. PMID: 19883614
  39. results suggest that the effects of CCK on the HPA axis and on food intake may, at least in part, be mediated by nesfatin-1-ir neurons in the PVN. PMID: 19540880
  40. Data suggest that some nesfatin-1 neurons of both the hypothalamus and brainstem are sensitive to peripheral inflammatory signals, and that centrally released nesfatin-1 may contribute to the neural mechanisms leading to endotoxemic anorexia. PMID: 19778412
  41. Nefstatin-1 is distributed to several discrete nuclei in brainstem and interacts with G protein-coupled receptor, leading to increase of [Ca(2+)](i), which is linked to protein kinase A activation in cultured rat hypothalamic neurons. PMID: 17627999
  42. Seizure rats had a decreased expression of ghrelin while there was an elevated expression of Nesfatin-1 in hypothalamus. PMID: 21418984
  43. indicate that glucose-responsive nesfatin-1 regulates insulin secretion, glucose homeostasis, and whole-body energy balance in rats PMID: 21828181
  44. results indicate that the central nesfatin-1 system is stimulated by stress and activates CRH, NA and 5-HT neurons and hypothalamic-pituitary-adrenal axis, evoking both central and peripheral stress responses PMID: 20966530
  45. These data provide the first evidence for possible participation of NUCB2 in the stress-axis regulation, both at the level of the brainstem and in the hypothalamus PMID: 20435076
  46. NUCB2/nesfatin-1 plays an indispensable role in the central networks driving puberty onset in the female rats. PMID: 20534827
  47. nesfatin-1/NUCB2 immunoreactive cells were localized in the central part of the pancreatic islets, the lower third and middle portion of the gastric mucosal gland, and the submucous layer of the duodenum PMID: 20380005
  48. Data established nesfatin-1 neurons in specific nuclei of the brain as part of the neuronal response to abdominal surgery and suggest a possible implication of nesfatin-1 in alterations of food intake and gastric transit associated with such a stressor. PMID: 19944727
  49. The release of NUCB2 from isolated islets was significantly elevated following glucose challenge. PMID: 20032201
  50. Since NEFA is a peripheral luminal membrane constituent, its distinct trafficking from the transmembrane marker mannosidase II suggests a novel Golgi retention mechanism. PMID: 11893086

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Subcellular Location
Golgi apparatus. Endoplasmic reticulum. Nucleus envelope. Membrane; Peripheral membrane protein. Cytoplasm. Secreted.; [Nesfatin-1]: Secreted.
Protein Families
Nucleobindin family
Database Links

KEGG: rno:59295

UniGene: Rn.41602

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