OAZ1 Antibody

1. Data show the the interplay between the enzyme ornithine decarboxylase (ODC) and two regulatory proteins: antizyme (Az) and inhibitor (AzIN). PMID: 26305948
2. the effects of AZ on cell growth are independent of polyamines. PMID: 24930035
3. Results show that ornithine decarboxylase antizyme 1 (OAZ1) simultaneously inhibits the proliferation and induces the differentiation of oral cancer cells. PMID: 25318549
4. To further understand its functions in CML pathogenesis, OAZ1 was overexpressed, and PCR array analysis was used to monitor the expression of key genes commonly involved in leukemia development. PMID: 24192781
5. Gene expression studies have identified altered expression of ornithine decarboxylase antizyme 1 in suicide completers with a history of mood disorders. PMID: 23260169
6. This study demomistrated that H3K4me3 modification plays an important role in up regulation of AOAZ1 in prefrontal cortex. PMID: 22008221
7. In the absence of amino acids, mTORC1 is inhibited, whereas mTORC2 is activated, leading to the inhibition of global protein synthesis and increased AZ1 synthesis via a cap-independent mechanism. PMID: 22157018
8. AZ_95-176 is the minimal AZ peptide that is fully functioning in the binding of ODC and AZI and inhibition of their function. PMID: 21931692
9. the differences in residues 125 and 140 in ODC and AZI are responsible for the differential antizyme-binding affinities PMID: 21552531
10. Data show that OAZ promotes the removal of Mps1 from centrosomes, and centrosome overproduction caused by reducing OAZ activity requires Mps1. PMID: 20861309
11. These data together demonstrate the existence of a c-Jun-dependent mechanism regulating the abundance of the antiapoptotic DNp73 in response to genotoxic stress. PMID: 20185758
12. Human AZI is capable of acting as a general inhibitor for all members of the antizyme family. PMID: 15355308
13. Special polymorphism haplotype of OAZ gene is associated with Chinese systemic lupus erythematosus. OAZ may suggest a new pathway for lupus. PMID: 15476163
14. This study also suggests that highly expressed AZI may be partly responsible for increased ODC activity and cellular transformation. PMID: 15670771
15. OAZ can alter the intensity and duration of the BMP4 stimulus through Smad6 PMID: 16373339
16. Ornithine decarboxylase antizyme 1 enhances the ability of UM1 human oral squamous cancer cells to repair DNA double-strand breaks by the nonhomologous end-joining pathway. PMID: 17630775
17. Identified the OAZ1+2222A/G polymorphism as a potential genetic marker of vascular events. PMID: 17761941
18. Yeast antizyme mediates degradation of yeast ornithine decarboxylase by yeast but not by mammalian proteasome: new insights on yeast antizyme PMID: 18089576
19. Data suggest that residue 331 may play a major role in the dimerization of AZI, and the mutating Ser-331 to Tyr in AZI (AZI-S331Y) caused a shift from a monomer configuration to a dimer. PMID: 19635796
20. antizyme expression requires programmed, ribosomal frameshifting PMID: 7813017

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HGNC: 8095

OMIM: 601579

KEGG: hsa:4946

STRING: 9606.ENSP00000464146

UniGene: Hs.446427