OBSCN Antibody, FITC conjugated

Datasheet
Code CSB-PA729422LC01HU
Size US$299
Uniprot No. Q5VST9
Immunogen Recombinant Human Obscurin protein (1621-1712AA)
Raised in Rabbit
Species Reactivity Human
Tested Applications ELISA
Relevance Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle (PubMed:11448995, PubMed:16205939). Has serine/threonine protein kinase activity and phosphorylates N-cadherin CDH2 and sodium/potassium-transporting ATPase subunit ATP1B1 (By similarity).
Form Liquid
Conjugate FITC
Storage Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Purification Method >95%, Protein G purified
Isotype IgG
Clonality Polyclonal
Alias Obscurin (EC 2.7.11.1) (Obscurin-RhoGEF) (Obscurin-myosin light chain kinase) (Obscurin-MLCK), OBSCN, KIAA1556 KIAA1639
Immunogen Species Homo sapiens (Human)
Protocols ELISA Protocol
Research Area Signal Transduction
Target Names OBSCN
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
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Function Structural component of striated muscles which plays a role in myofibrillogenesis. Probably involved in the assembly of myosin into sarcomeric A bands in striated muscle
Involvement in disease A chromosomal aberration involving OBSCN has been found in Wilms tumor. Translocation t(1;7)(q42;p15) with PTHB1.
Subcellular Location Isoform 3: Cytoplasm, myofibril, sarcomere, M line, Cytoplasm, myofibril, sarcomere, Z line, Note=In differentiating skeletal muscle cells, isoform 3 primarily localizes to the sarcomeric M-line and less frequently to the Z-disk (PubMed:12527750), Isoform 3 colocalizes with ANK1 isoform Mu17/ank15 at the M-line in differentiated skeletal muscle cells (PubMed:12527750), SUBCELLULAR LOCATION: Cytoplasm, myofibril, sarcomere, M line, Cytoplasm, myofibril, sarcomere, Z line, Cell membrane, sarcolemma, Nucleus
Protein Families Protein kinase superfamily, CAMK Ser/Thr protein kinase family
Database Links

HGNC: 15719

OMIM: 608616

KEGG: hsa:84033

UniGene: Hs.650039

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