OIP5 Antibody

1. LncRNA OIP5-AS1 suppressed cell viability, promoted radio-induced apoptosis, and enhanced the radiosensitivity of CRC cells by regulating DYRK1A expression through miR-369-3p. PMID: 29773344
2. LncRNA OIP5-AS1 modulated the expression of Bcl-2 by targeting miR-448 in lung adenocarcinoma cells. PMID: 29247949
3. interaction network might function as an oncogene in bladder cancer progression PMID: 28843748
4. The authors demonstrate that CDK1 controls Mis18 complex recruitment to centromeres by regulating oligomerization of M18BP1 through the Mis18alpha:Mis18beta scaffold. PMID: 28059702
5. High OIP5 expression is associated with bladder cancer. PMID: 28752236
6. Mitofusin 2 knockdown altered Neisseria gonorrhoeae opacity-associated-interacting protein 5 (OIP5) expression. PMID: 29034772
7. These findings suggest that OIP5 may be involved in hepatocellular carcinoma (HCC) growth and metastasis and that miR-15b-5p inhibits OIP5-mediated oncogenic signaling in HCC. PMID: 28184024
8. the Mis18 complex contains dual CENP-C recognition motifs that are combinatorially required to generate robust centromeric localization that leads to CENP-A deposition PMID: 27239045
9. OIP5 over-expression inhibited hsa-miR-139-5p expression, antagonized its functions and led to the de-repression of its endogenous target NOTCH1, which was a core oncogene in promoting breast cancer progression. PMID: 27916718
10. Stable binding of Mis18alpha-Mis18beta heterotetramer to centromeres in telophase licenses them for CENP-A deposition. PMID: 26942680
11. Over-expression of OIP5 was observed in breast tumors. PMID: 26107214
12. Mis18beta binds with and specifies the centromere localization of HJURP. PMID: 24519934
13. this study showed betaTrCP-mediated regulation of Mis18beta stability is a mechanism to restrict centromere function of Mis18 complex from late mitosis to early G1 phase. PMID: 24269809
14. expression of AURKC, OIP5, PIWIL2 and TAF7L differed between patients with Acute myeloid leukemia, myelodysplastic syndrome and healthy controls in a gender-dependent manner PMID: 23292864
15. OIP5 expression was significantly associated with poor prognosis of lung and esophageal cancer patients PMID: 22129094
16. These results indicate that knockdown of OIP5 may induce apoptosis in cancer cells. PMID: 20510019
17. Three human proteins essential for centromere/kinetochore structure and function, hMis18alpha, hMis18beta, and M18BP1, the complex of which is accumulated specifically at the telophase-G1 centromere, are identified.[Mis18alpha, Mis18beta, M18BP1] PMID: 17199038

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HGNC: 20300

OMIM: 606020

KEGG: hsa:11339

STRING: 9606.ENSP00000220514

UniGene: Hs.661645