PAFAH1B1 Antibody

1. Platelet-activating factor increases reactive oxygen species-mediated microbicidal activity of human macrophages infected with Leishmania braziliensis. PMID: 28830073
2. LIS1 promotes dynactin-dependent tracking of dynein on both growing and shrinking plus ends. LIS1 also increases the frequency and velocity of processive dynein movements that are activated by complex formation with dynactin and a cargo adaptor. PMID: 28406398
3. Microarray analysis after PAFAH1B1 knockdown and its overexpression indicated that the protein maintains Matrix Gla Protein expression PMID: 27124368
4. A novel recurrent LIS1 splice site mutation in classic lissencephaly have been found in two unrelated pediatric patients. PMID: 27891766
5. Lis1 has two opposing modes of regulating dynein, being capable of inducing both low and high affinity for the microtubule; study shows that these opposing modes depend on the stoichiometry of Lis1 binding to dynein and that this stoichiometry is regulated by the nucleotide state of dynein's AAA3 domain. PMID: 28886386
6. genetic variants in LIS1 may contribute to AML risk in Chinese population. PMID: 28076835
7. Val279Phe gene polymorphisms in PAF-AH are associated with PAF-AH activity and PAF and GMP-140 levels and may be a risk factor for Henoch-Schonlein purpura with gastrointestinal bleeding PMID: 28407821
8. There were no significant associations between R92H and A379V variants of PAF-AH gene and risk of polycystic ovary syndrome in Chinese women. PMID: 28320416
9. results indicate that the NAGK-dynein interaction with the involvements of Lis1 and NudE1 plays an important role in prophase nuclear envelope breakdown (NEB) and metaphase MT-KT attachment during eukaryotic cell division. PMID: 27646688
10. In testis: varied levels among samples of different spermatogenic abilities, protein expression restricted to spermatogonia, spermatocytes and spermatids. Also varied levels in unfertilized oocytes, zygotes, cleavage stage embryos and blastocysts. PMID: 26380866
11. Results showed that miR-144 was reduced in cholangiocarcinoma tissues and suggested that miR-144 may be an essential suppresser of cholangiocarcinoma cell proliferation and invasion through targeting LIS1. PMID: 25479763
12. LIS1 and TSNAX genes are not associated with susceptibility to bipolar I disorder in Chinese Han population. PMID: 24928020
13. Identify a key role for Lis1 in hematopoietic stem cells and mark its directed control of asymmetric division as a critical regulator of normal and malignant hematopoietic development PMID: 24487275
14. LIS1 gene duplication is associated with developmental, behavioral and brain abnormalities. PMID: 23813913
15. LIS1 is required for dynein-mediated transport induced by membrane tethering of BICD2-N and LIS1 contributes to dynein accumulation at microtubule plus ends and BICD2-positive cellular structures. PMID: 22956769
16. PAFAH1B1 overexpression contributes to lung tumorigenesis and poor prognosis. PMID: 22749159
17. Studies indicate that binding of dynactin, LIS1 and NudEL regulate cytoplasmic dynein motor activity. PMID: 22373868
18. The results did not detect a significant association. It indicated that common genetic variations in LIS1 genes might not play a role in the genetic predisposition to autism. PMID: 21890215
19. cell type-restricted role for LIS1 in large vesicular transport and quantitative support for a general role for LIS1 in high-load dynein functions. PMID: 22006948
20. Mutually exclusive cytoplasmic dynein regulation by NudE-Lis1 and dynactin. PMID: 21911489
21. we have identified a so-far-unknown interaction between LIS1 and PDE4 isoforms, whereby PDE4 can modulate LIS1-dynein complexes and dynein-dependent processes within cells by sequestering LIS1. PMID: 21652625
22. PAFAH Ib regulates endocytic membrane trafficking through novel mechanisms involving both PLA(2) activity and LIS1-dependent dynein function PMID: 21593204
23. these results suggest that LIS1 plays a potential tumor suppressor role in the development and progression of hepatocellular carcinoma. PMID: 21569763
24. Single nucleotide polymorphism in PAFAH1B1 gene is associated with Myelodysplastic Syndromes. PMID: 21107783
25. The truncated monomeric form of LIS1 had little effect on dynein motility, but an artificial dimer of truncated LIS1 suppressed dynein motility, which was restored by the N-terminal fragment of NDEL1. PMID: 21036906
26. Lis1 is cell-autonomously required for cortical neuron and astrocyte production and is involved in neuronal migration. PMID: 21092859
27. Findings suggest that physiological functions of LIS1 and NDEL1 in neurons have been ascribed for proteins fundamentally required for cell cycle progression and control. PMID: 20168084
28. NudC may be involved in the regulation of LIS1 stability by its chaperone function. PMID: 20675372
29. NudCL2, a homolog of Aspergillus NudC, which shares significant homology with human NudC and NudCL was identified. It regulates the LIS1/dynein pathway by stabilizing LIS1 with Hsp90 chaperone. PMID: 20133715
30. NDE1 and NDEL1 act upstream of LIS1 in dynein recruitment, and/or activation, on the membrane. PMID: 20048338
31. LIS1 has a principle role in brain development.Hemizygote mutations result in a severe brain malformation known as lissencephaly. It is a WD repeat protein involved in several protein complexes that may play a functional role in brain development. PMID: 11803439
32. Together, our data suggest a novel role for LIS1 in mediating CLIP-170-dynein interactions and in coordinating dynein cargo-binding and motor activities. PMID: 11889140
33. Val279Phe polymorphism is activity-deficient and is associated with increased risk of childhood atopic asthma. PMID: 11916011
34. LIS1, CLIP-170's key to the dynein/dynactin pathway PMID: 11940666
35. Lissencephaly with posteriorly predominant gyral abnormality is caused by mutations of the LIS1 gene on chromosome 17. PMID: 12185771
36. The propensity of monocytes in juvenile periodontitis patients to differentiate into monocyte-derived dendritic cells results in lower levels of PAFAH and allows platelet activating factor to promote production of a protective IgG2 antibody response. PMID: 12496397
37. LIS1 missense mutations result in variable phenotypes PMID: 12885786
38. LIS1 maps at 17p13.3 and is the result of a heterozygous mutation. It acts during corticogenesis on radial migratory pathways. PMID: 15057976
39. Our results indicate that Tat interacts with LIS1 in vitro and in vivo and that this interaction might contribute to the effect of Tat on microtubule formation. PMID: 15698475
40. V279F polymorphism in the plasma PAF-AH gene and consequent enzymatic deficiency is an important factor for IVIG nonresponse in Japanese patients with acute KD. PMID: 16027700
41. use of poliovirus protein as a research tool allowed us to reveal the role of cellular protein LIS1 in membrane protein trafficking, maintenance of Golgi integrity, surface presentation of unstable receptors PMID: 16138011
42. LIS1 RNA interference blocks neural stem cell division, morphogenesis, and motility at multiple stages. PMID: 16144905
43. Mutations within the LisH (LIS1 homology)motif are likely to result in pathogenic consequences in genes associated with genetic diseases. PMID: 16258276
44. in addition to migration, disruption in cell proliferation could play a more important role in the development of lissencephaly than previously suspected PMID: 16642511
45. Our results show that inhibition of PP2A by LIS1 induces HIV-1 transcription. Our results also point to a possibility that LIS1 might function in the cells as a yet unrecognized regulatory subunit of PP2A. PMID: 17018134
46. Neither type nor position of intragenic mutations in the LIS1 gene allows prediction of the phenotypic severity. Patients presenting with mild cerebral malformations should be considered for genetic analysis of the LIS1 gene. PMID: 17664403
47. LIS1 has a role in lissencephaly, neuronal migration and development [review] PMID: 17850624
48. The high frequency of genomic deletions/duplications of LIS1 is in keeping with the over representation of Alu elements in the 17p13.3 region. PMID: 18285425
49. LIS1 regulates cytoplasmic dynein and plays an important role on the determination cleavage plane of neuronal progenitor cells. PMID: 18421979
50. regulates cytoplasmic dynein. [review] PMID: 18524253

Show More

Hide All

HGNC: 8574

OMIM: 247200

KEGG: hsa:5048

STRING: 9606.ENSP00000380378

UniGene: Hs.77318