PAIP2 Antibody, FITC conjugated

Code CSB-PA859027LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PAIP2 Polyclonal antibody
Uniprot No.
Target Names
PAIP2
Alternative Names
PABP-interacting protein 2 antibody; PAIP-2 antibody; PAIP2 antibody; PAIP2_HUMAN antibody; poly(A) binding protein interacting protein 2 antibody; Poly(A)-binding protein-interacting protein 2 antibody; Polyadenylate-binding protein-interacting protein 2 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Polyadenylate-binding protein-interacting protein 2 protein (1-127AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Acts as a repressor in the regulation of translation initiation of poly(A)-containing mRNAs. Its inhibitory activity on translation is mediated via its action on PABPC1. Displaces the interaction of PABPC1 with poly(A) RNA and competes with PAIP1 for binding to PABPC1. Its association with PABPC1 results in disruption of the cytoplasmic poly(A) RNP structure organization.
Gene References into Functions
  1. Paip2 is a host antiviral restriction factor antagonized by PABP accumulation in HCMV-infected cells PMID: 23964095
  2. Role of PAIP2 in modulation of GLUT5 mRNA stability. PMID: 12820898
  3. PAIP2 is a crucial regulator of VEGF mRNA and has a role in regulating angiogenesis PMID: 15175342
  4. The turnover of Paip2 in the cell is mediated by EDD and is regulated by PABP. PMID: 16601676
Subcellular Location
Cytoplasm.
Protein Families
PAIP2 family
Tissue Specificity
Expressed at highest level in testis, but also abundant in brain, cervix, lung, ovary, placenta, adipose tissue, thymus and thyroid.
Database Links

HGNC: 17970

OMIM: 605604

KEGG: hsa:51247

STRING: 9606.ENSP00000265192

UniGene: Hs.396644

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7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
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