PASK Antibody, HRP conjugated

1. PASK phosphorylates and inactivates GSK3beta, thereby preventing PDX-1 serine phosphorylation and alleviating GSK3beta-mediated PDX-1 protein degradation in pancreatic beta-cells. PMID: 23853095
2. Mutations that affect PAS domain cause a severe protein trafficking defect and change the interactions with Kv11.1 channels. PMID: 23721480
3. The role of PAS kinase in PASsing the glucose signal. PMID: 22219681
4. Per-Arnt-Sim (PAS) domain-containing protein kinase (PASK) has a role in insulin hypersecretion PMID: 22065581
5. PASK is involved in the regulation of glucagon secretion by glucose and may be a useful target for the treatment of type 2 diabetes. PMID: 21181396
6. Structural bases of PAS domain-regulated kinase (PASK) activation in the absence of activation loop phosphorylation. PMID: 20943661
7. molecular cloning, gene expression, and comparison with mouse protein PMID: 11688972
8. Results suggest that elevated glucose concentrations rapidly increase Per-Arnt-Sim kinase activity in pancreatic islet beta cells, followed by up-regulation by glucose of preproinsulin and pancreatic duodenum homeobox 1 gene expression. PMID: 15148392
9. identified the multifunctional eukaryotic translation elongation factor eEF1A1 as a novel interaction partner of PASKIN in the nuclei of testis germ cells and in the midpiece of sperm tails PMID: 17595531

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HGNC: 17270

OMIM: 607505

KEGG: hsa:23178

STRING: 9606.ENSP00000234040

UniGene: Hs.397891