PCM1 Antibody

Code CSB-PA618977DSR2HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Immunohistochemistry of paraffin-embedded human tonsil tissue using CSB-PA618977DSR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA618977DSR2HU at dilution of 1:100

Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PCM1 Polyclonal antibody
Uniprot No. Q15154
Target Names PCM1
Alternative Names hPCM-1 antibody; PCM-1 antibody; pcm1 antibody; PCM1_HUMAN antibody; Pericentriolar material 1 antibody; Pericentriolar material 1 protein antibody; PTC4 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Pericentriolar material 1 protein (1-260AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Earn $30 Amazon Card or 20μL/μg CUSABIO Trial Size Antibody. Details of rewards >>

Target Data

Function Required for centrosome assembly and function. Essential for the correct localization of several centrosomal proteins including CEP250, CETN3, PCNT and NEK2. Required to anchor microtubules to the centrosome. Involved in the biogenesis of cilia.
Gene References into Functions
  1. In the absence of PCM1, Mib1 destabilizes Talpid3 through poly-ubiquitylation and suppresses cilium assembly. PMID: 27146717
  2. Data suggest that USP9X as an integral component of centrosome where it functions to stabilize PCM1 and CEP55 and to promote centrosome biogenesis; N-terminal domain of USP9X appears to be responsible for physical association of USP9X with PCM1 and CEP55. (USP9X = ubiquitin-specific protease 9X; PCM1 = pericentriolar material 1 protein; CEP55 = 55kDa centrosomal protein) PMID: 28620049
  3. a novel variant in the PCM1 3'UTR is significantly associated with ovarian cancer PMID: 24909162
  4. no association between the PCM1 gene and schizophrenia in a Japanese population PMID: 24576429
  5. Haematological neoplasms associated with t(8;9)(p22;p24); PCM1-JAK2 have features in common and we suggest that they should be recognized as a specific entity in the WHO classification PMID: 24913195
  6. these data suggest a mechanism whereby the recruitment of Plk1 to pericentriolar matrix by PCM1 plays a pivotal role in the regulation of primary cilia disassembly before mitotic entry. PMID: 23345402
  7. Chromosomal translocation [t(8;9)(p22;p24)]/PCM1-JAK2 fusion protein activates SOCS2 and SOCS3 via STAT5 in a cutaneous T-cell lymphoma cell line. PMID: 23372669
  8. CEP90 physically interacts with PCM-1 at centriolar satellites, and this interaction is essential for centrosomal accumulation of the centriolar satellites and eventually for primary cilia formation. PMID: 23110211
  9. PCM1 interacts with Hook2 in a complex that regulates a limiting step required for further initiation of ciliogenesis after centriole maturation. PMID: 21998199
  10. NEK7 is essential for PCM accumulation in a cell cycle stage-specific manner. PMID: 22100915
  11. WT HTT regulates ciliogenesis by interacting through huntingtin-associated protein 1 (HAP1) with pericentriolar material 1 protein (PCM1). PMID: 21985783
  12. The data failed to find a significant association between SNPs or haplotypes of the PCM1 gene and schizophrenia in the Japanese population (P>0.28). PMID: 21481569
  13. These data provide further evidence that PCM1-though certainly not a major risk factor in the Northern Swedish population-cannot be ruled out as a contributor to schizophrenia risk and/or protection. PMID: 20468070
  14. DISC1 coding variants modulate centrosomal PCM1 localization, highlight a role for DISC1 in glial function and provide a possible cellular mechanism contributing to the association of these DISC1 variants with psychiatric phenotypes. PMID: 20360304
  15. Hook3- and PCM1-mediated dynamic assembly of pericentriolar material is essential for interkinetic nuclear migration. PMID: 20152126
  16. multiple processes involved in regulating the abundance of NIMA (never in mitosis gene a)-related kinase 2 kinase at the centrosome including microtubule binding, the centriolar satellite component PCM-1, and localized protein degradation PMID: 15659651
  17. To study the rearrangement created by the t(8;9)(p22;p24)used dual-colour FISH on metaphases from patient cells using labelled-BAC clones centred on PCM1. PMID: 16034466
  18. A genetic translocation in atypical chronic myeloid leukemia yields a new PCM1-JAK2 fusion gene. PMID: 16091753
  19. The PCM1 gene is implicated in susceptibility to schizophrenia and is associated with orbitofrontal gray matter volumetric deficits. PMID: 16894060
  20. cytogenetic change of t(8;9)(p22;p24) may induce HLA-DR immunophenotypic switch and a coordination of the two evolutional changes may play a role in leukemic cell progression PMID: 18594780
  21. PCM1 gene is implicated in schizophrenia. PMID: 18762586
  22. CEP290 binds to PCM-1 and localizes to centriolar satellites in a PCM-1- and microtubule-dependent manner. PMID: 18772192
  23. decreased colocalization of DISC1 and its binding partner PCM1 after Phe607 DISC1 transfection PMID: 19455170

Show More

Hide All

Involvement in disease A chromosomal aberration involving PCM1 is found in papillary thyroid carcinomas (PTCs). Translocation t(8;10)(p21.3;q11.2) with RET links the protein kinase domain of RET to the major portion of PCM1.
Subcellular Location Cytoplasm, cytoskeleton, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, Cytoplasmic granule, Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriolar satellite, Cytoplasm, cytoskeleton, cilium basal body
Protein Families PCM1 family
Tissue Specificity Expressed in blood, bone marrow, breast, lymph node, ovary and thyroid.
Database Links

HGNC: 8727

OMIM: 600299

KEGG: hsa:5108

STRING: 9606.ENSP00000327077

UniGene: Hs.491148

Newsletters

Get all the latest information on Events, Sales and Offers. Sign up for newsletter today.

© 2007-2021 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1