PCSK5 Antibody

1. loss of the convertase furin or PC5/6 in hepatocytes results in a approximately 30% decrease in APC levels, with no significant contribution from PACE4. We conclude that prior convertase cleavage of protein C in hepatocytes is critical for its thrombin activation. PMID: 28468828
2. Case Report: whole exome sequencing of a case with the VACTERL association uncovered a novel frameshift mutation in the PCSK5 gene. PMID: 26055999
3. full-length alpha-DG in the human endometrial epithelium is a barrier for embryo attachment and that removal of alpha-DG-N by proprotein convertase 5/6 (PC6; a protease critical for implantation PMID: 26077903
4. Proprotein convertase 5/6 cleaves PDGFA in the human endometrium in preparation for embryo implantation. PMID: 25429785
5. PC5/6A is involved in squamous differentiation of human nasal epithelial cells, possibly through up-regulation of the BMP-2 signaling pathway. PMID: 25350918
6. study implicates PC6 as a key regulatory protein essential for the attachment of the blastocyst to the endometrial epithelium through the processing of pro-integrin-alphas PMID: 22740495
7. PC6 plays a key role in regulating fundamental cellular remodeling processes, such as plasma membrane transformation and membrane-cytoskeletal interface reorganization. PMID: 21971156
8. Latent transforming growth factor beta-binding proteins-2 and -3 inhibit the proprotein convertase 5/6A. PMID: 21700711
9. PC6 may have a role in uterine receptivity and its uterine lavage levels appear to be significantly lower in a subgroup of women with unexplained infertility PMID: 21273245
10. PTPkappa was scissored by the processed form of proprotein convertase 5, and galectin-3 binding protein which is over-produced in colon cancer cells and tissues. PMID: 21094132
11. The proteolytic activation and thus bioavailability of BMP2 is controlled by PC6. PMID: 20555025
12. Variability at the PCSK5 locus influences high-density lipoprotein cholesterol levels. PMID: 20031622
13. Results describe the mechanisms of PC6 action in decidualization and identify caldesmon as one of its physiological substrates. PMID: 19764806
14. PC5/6 plays a key role for decidualization in human endometrium. PMID: 15522936
15. PC6 is an essential molecule in modulating uterine function to support the establishment of embryo implantation PMID: 15601911
16. in binding VEGFR-2, furin and PC5 promote cleavage of N-and C-terminal VEGF-D propeptides, whereas PC7 promotes cleavage of the C-terminal propeptide only PMID: 17242158
17. after stimulation, the protease activity of PC5A is enhanced, as evidenced by the cleavage of the PC5A substrates Lefty, ADAMTS-4, endothelial lipase, and PCSK9. PMID: 18039650
18. We propose that Pcsk5, at least in part via GDF11, coordinately regulates caudal Hox paralogs, to control anteroposterior patterning, nephrogenesis, skeletal, and anorectal development. PMID: 18519639

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HGNC: 8747

OMIM: 600488

KEGG: hsa:5125

STRING: 9606.ENSP00000446280

UniGene: Hs.368542