PDP1 Antibody, HRP conjugated

Code CSB-PA878946LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PDP1 Polyclonal antibody
Uniprot No.
Target Names
PDP1
Alternative Names
[Pyruvate dehydrogenase [acetyl transferring]] phosphatase 1; mitochondrial antibody; [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1 antibody; FLJ32517 antibody; Gm1024 antibody; MGC119646 antibody; mitochondrial antibody; PDH antibody; PDP 1 antibody; PDP antibody; Pdp1 antibody; PDP1_HUMAN antibody; PDPC 1 antibody; PDPC antibody; PPM2C antibody; Protein phosphatase 2C antibody; protein phosphatase 2C; magnesium dependent; catalytic subunit antibody; Pyruvate dehydrogenase (Lipoamide) phosphatase phosphatase antibody; Pyruvate dehydrogenase phosphatase catalytic subunit 1 antibody; Pyruvate dehydrogenase phosphatase; catalytic subunit 1 antibody; RP23 203A12.1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human [Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 1, mitochondrial protein (1-154AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Catalyzes the dephosphorylation and concomitant reactivation of the alpha subunit of the E1 component of the pyruvate dehydrogenase complex.
Gene References into Functions
  1. High PDH expression is associated with glucose intolerance. PMID: 28148899
  2. YB-1 phosphorylation at Ser-102 is an important prerequisite for CCL5 promoter activation during macrophage differentiation PMID: 24962578
  3. the pyruvate dehydrogenase complex is regulated by Tyr phosphorylation of PDP1, which toggles recruitment between ACAT1 and SIRT3 PMID: 24486017
  4. Although 7 days of bed rest induced whole body glucose intolerance, exercise-induced PDH regulation in skeletal muscle was not changed, suggesting that exercise-induced PDH regulation in skeletal muscle is maintained in glucose-intolerant individuals. PMID: 21680880
  5. catalytic subunit of PDP1 crystals belonged to space group P4(1)2(1)2 or P4(3)2(1)2, with unit-cell parameters a = b = 65.1, c = 216.1 A. PMID: 20208177
  6. pyruvate dehydrogenase phosphatase PDP1 is down-regulated in circulating lymphocytes of obese subjects because it is poorly sensitive to magnesium/calcium; this defect is attenuated when plasma insulin is greatly enhanced PMID: 15897476
  7. Lower accumulation of free ADP and AMP after the FAT-adapt trial may be responsible for the decreased glycogenolysis and PDH activation during sprinting. PMID: 16188909
  8. Functional characterization of the bovine counterpart. PMID: 8396421
  9. Functional characterization of the rat counterpart. PMID: 9651365
  10. In cultured skin fibroblasts from three patients with congenital lactic acidemia due to a defect in activation of the pyruvate dehydrogenase complex, the PDP-activity was significantly reduced to 50.7%, 64.6% and 63.1% of that of control fibroblasts. PMID: 1327585
  11. In postmortem tissue samples, from male child with metabolic acidosis, PDK normally reduced PDH-activity in ATP-presence. Addition of Ca++ and Mg++ did not restored PDH-activity. The defect was attributed to a markedly reduced PDP-activity. PMID: 172850

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Involvement in disease
Pyruvate dehydrogenase phosphatase deficiency (PDP deficiency)
Subcellular Location
Mitochondrion matrix.
Protein Families
PP2C family
Database Links

HGNC: 9279

OMIM: 605993

KEGG: hsa:54704

STRING: 9606.ENSP00000379503

UniGene: Hs.22265

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