PDZRN3 Antibody, FITC conjugated

Code CSB-PA891797LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PDZRN3 Polyclonal antibody
Uniprot No.
Target Names
PDZRN3
Alternative Names
E3 ubiquitin-protein ligase PDZRN3 antibody; KIAA1095 antibody; Ligand of Numb protein X 3 antibody; likely ortholog of mouse semaF cytoplasmic domain associated protein 3 antibody; LNX3 antibody; PDZ domain containing ring finger 3 antibody; PDZ domain-containing RING finger protein 3 antibody; Pdzrn3 antibody; Protein SEMACAP3 antibody; PZRN3_HUMAN antibody; SEMACAP3 antibody; Semaphorin cytoplasmic domain associated protein antibody; Semaphorin cytoplasmic domain-associated protein 3 antibody; SEMCAP3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human E3 ubiquitin-protein ligase PDZRN3 protein (133-404AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
E3 ubiquitin-protein ligase. Plays an important role in regulating the surface level of MUSK on myotubes. Mediates the ubiquitination of MUSK, promoting its endocytosis and lysosomal degradation. Might contribute to terminal myogenic differentiation.
Gene References into Functions
  1. Authors show that HPV-16 and HPV-18 E6 can target PDZRN3 in a PDZ- and proteasome-dependent manner and provide a connection between the papillomavirus life cycle and differentiation-related STAT signaling. PMID: 25355882
  2. a novel partner of Kidins220/ARMS PMID: 22609016
  3. These results indicate that PDZRN3 plays an important role in negative feedback control of BMP-2-induced osteoblast differentiation in C2C12 cells through inhibition of Wnt3a-beta-catenin signaling. PMID: 20668165
Subcellular Location
Cell junction, synapse. Cytoplasm.
Tissue Specificity
Widely expressed, including in the heart, skeletal muscle and liver and, at lower levels, in the brain, colon, small intestine, placenta and lung. Down-regulated in ovarian serous papillary tumors.
Database Links

HGNC: 17704

OMIM: 609729

KEGG: hsa:23024

STRING: 9606.ENSP00000263666

UniGene: Hs.660347

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