PER3 Antibody

Code CSB-PA017788LA01HU
Size US$299Purchase it in Cusabio online store
(only available for customers from the US)
Image
  • Western Blot
    Positive WB detected in: Hela whole cell lysate, Mouse skeletal muscle tissue
    All lanes: PER3 antibody at 4µg/ml
    Secondary
    Goat polyclonal to rabbit IgG at 1/50000 dilution
    Predicted band size: 132, 133 kDa
    Observed band size: 132 kDa

  • Immunohistochemistry of paraffin-embedded human ovarian cancer using CSB-PA017788LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human colon cancer using CSB-PA017788LA01HU at dilution of 1:100

  • Immunofluorescent analysis of Hela cells using CSB-PA017788LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PER3 Polyclonal antibody
Uniprot No. P56645
Target Names PER3
Alternative Names 2810049O06Rik antibody; Cell growth inhibiting gene 13 protein antibody; Cell growth-inhibiting gene 13 protein antibody; Circadian clock protein PERIOD 3 antibody; GIG13 antibody; gPER3 antibody; Growth inhibiting protein 13 antibody; HGNC:8847 antibody; hPER3 antibody; mPer3 antibody; Per3 antibody; PER3_HUMAN antibody; Period 3 antibody; Period circadian clock 3 antibody; Period circadian protein 3 antibody; Period circadian protein homolog 3 antibody; Period homolog 3 (Drosophila) antibody; Period homolog 3 antibody; Period homolog 3; Drosophila antibody; Period3 antibody
Raised in Rabbit
Species Reactivity Human, Mouse
Immunogen Recombinant Human Period circadian protein homolog 3 protein (1-131AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method >95%, Protein G purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form Liquid
Tested Applications ELISA, WB, IHC, IF
Recommended Dilution
Application Recommended Dilution
WB 1:500-1:5000
IHC 1:20-1:200
IF 1:50-1:200
Protocols ELISA Protocol
Western Blotting(WB) Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Originally described as a core component of the circadian clock. The circadian clock, an internal time-keeping system, regulates various physiological processes through the generation of approximately 24 hour circadian rhythms in gene expression, which are translated into rhythms in metabolism and behavior. It is derived from the Latin roots 'circa' (about) and 'diem' (day) and acts as an important regulator of a wide array of physiological functions including metabolism, sleep, body temperature, blood pressure, endocrine, immune, cardiovascular, and renal function. Consists of two major components
Gene References into Functions
  1. Study identified several CpG sites and specifically several CpGs in the PTPRS and PER3 genes differentially methylated between obese and non-obese children, suggesting a role for DNA methylation concerning development of childhood obesity. PMID: 28614626
  2. these findings suggest that rhythmic expression of the circadian clock gene PER3 is associated with the amount of daily physical activity and physical fitness in older adults PMID: 28045078
  3. PER3 polymorphisms links with chronotype and affective dimensions PMID: 28708003
  4. data suggest that, PER3(4/4) genotype may accelerate the course of disease in multiple sclerosis susceptible individuals especially in women PMID: 29055480
  5. The impact of PER3 polymorphisms on sleep cycle and insomnia in older adults is reported. PMID: 28276850
  6. there is a significant association between the PER3 polymorphism and the extraversion personality trait PMID: 28055273
  7. PER34/4 genotype may accelerate the course of disease in multiple sclerosis susceptible individuals. PMID: 29055479
  8. CLOCK rs1801260*C and PER3(4/4) influence myelination processes by regulating sleep quality and quantity. PMID: 27996307
  9. 4 and 5 variable-number tandem-repeat polymorphisms appear to influence sensitivity to the effects of stressful urban environments on sleep PMID: 27593530
  10. Data suggest that three E box-like response elements are located upstream of PER3 transcription start sites; these response elements appear to additively contribute to cell-autonomous transcriptional oscillation of PER3 and other circadian proteins. PMID: 28821614
  11. This study showed that Lack of Association between Genetic Polymorphism of PER3 gene with Late Onset Depression and Alzheimer's Disease in a Sample of a Brazilian Population PMID: 27335043
  12. This study shown a possible association between Per3 polymorphism and consciousness recovery level in Disorders of Consciousness patients. PMID: 26359345
  13. PER3 variants may be associated with decreased risk for depressive symptoms, including subthreshold levels of depressive symptoms, in older adults. PMID: 25892098
  14. The PER1 c.2884C > G polymorphism and PER3 54bp VNTR were associated with annual percent changes in bone mineral density of femoral neck after 1 year of hormone therapy. PMID: 26624862
  15. PER3 polymorphism is associated with sleep quality after a mild traumatic brain injury. PMID: 26440425
  16. PER3 VNTR polymorphism influences both response to antidepressant chronotherapeutics and total sleep time after the repeated sleep deprivation treatment in patients with bipolar depression. PMID: 26707349
  17. No association between cluster headache, PER3 VNTR polymorphism and chronotype was found in this study. PMID: 26922944
  18. There was no significant association between the PER3 VNTR polymorphism and the irregularity of the menstrual cycle in Korean adolescents. PMID: 26453284
  19. A role for PER3 in modulating circadian clock and mood during seasonal changes PMID: 26903630
  20. This work suggests a role of PER3 rs10462020 in predicting a prognosis in Diffuse large B-cell lymphoma overall survival of patients. PMID: 26406960
  21. evidence of an association between PER3 gene and planning performance in a sample of healthy subjects PMID: 25798540
  22. PER3 VNTR genotype does not explain the difference in chronotype between South African and Dutch marathon runners PMID: 26102236
  23. minor polymorphisms of PER3 may be associated with poor morning gastric motility, and may have a combinatorial effect with CLOCK. PMID: 25775462
  24. The findings support the notion that PER3 polymorphisms could be a potential genetic marker for an individual's circadian and sleep phenotypes. PMID: 25201053
  25. PER3 long allele carriers were more vulnerable to sleep-loss associated attentional lapses than those with the short allele. PMID: 25940842
  26. length polymorphism in the Period 3 gene is associated with sleepiness and maladaptive circadian phase in night-shift workers PMID: 25545397
  27. In patients with non-small cell lung cancer, those with lower expression of Per1, Per2 and Per3 had a shorter survival time than those with higher expression. PMID: 25550826
  28. PERIOD3 clock gene length polymorphism may have a role in colorectal adenoma formation PMID: 25501848
  29. The data indicate that humans homozygous for the PER3(5/5) allele are more sensitive to NIF light effects, as indexed by specific changes in sleep EEG activity. PMID: 24893318
  30. no evidence supporting a global association of PER3 genetic variants with the incidence of cancer (Meta-Analysis) PMID: 25837749
  31. The polymorphisms studied in PER3 did not demonstrate any relationship with Bone Mineral Density or the odds of osteoporosis in postmenopausal Korean women. PMID: 24678593
  32. Provide some evidence that circadian rhythm of flight cadets with the PER3 (5) allele are less likely to be affected compared to those with the PER3 (4) allele. PMID: 25400784
  33. A wild genotype of rs228729 in PER3 was the primary risk factor contributing to Chinese hepatocellular carcinoma patients recurrence-free survival. PMID: 25344870
  34. An association is outlined of Per3 five repeat allele with T2DM occurrence and suggest that individuals with five repeat allele may be at a greater risk for T2DM as compared to those carrying the four repeat allele. PMID: 25390010
  35. PER3, at least partially, was targeted by miRNA-103, which might affect cells apoptosis in G2/M phase by modulating apoptosis-related gene in p53 pathway. PMID: 24393525
  36. Per3 VNTR may contribute to modulation of cardiac functions and interindividual differences in development and progression of myocardial infarction PMID: 24866331
  37. Per3 variable number tandem repeat polymorphism is not a major risk factor for chronic heart failure (CHF) or a factor modulating the severity of the CHF in this population. PMID: 23128810
  38. there is significant association between diurnal preference and a polymorphism in PER3 and a novel nominally significant association between diurnal preference and a polymorphism in ARNTL2 PMID: 24635757
  39. Five SNPs (rs228727, rs228644, rs228729, rs707467, rs104620202) in the period 3 (PER3) gene are significant correlation with genotype and allele frequency in lung cancer. PMID: 24821610
  40. No association with SNPs or haplotypes of the PER3 gene was observed in prophylactic lithium response. PMID: 24636202
  41. there is a greater detrimental impact of sleep deprivation in PER3(5/5) than PER3(4/4) carriers. the group with greater attentional performance impairment due to sleep deprivation (PER3(5/5) carriers) is superior at initiating sleep over the 24-h cycle. PMID: 24439663
  42. Women with the 4/5 or 5/5 PER3 genotype had a nonstatistically significant 33% increased odds of breast cancer. PMID: 24903750
  43. PER3 genotype predicted circadian rhythm period lengthening by lithium, specifically among bipolar disorder cases. PMID: 24150227
  44. the association of rs934945 with "morning alertness" and rs2640909 with "morningness". PMID: 23969301
  45. there is significant daily variation in PER2, PER3, and ARNTL1 expression with earlier timing of expression in women than in men PMID: 23606611
  46. polymorphisms more behaviorally salient with increasing severity and/or duration of sleep restriction PMID: 23171222
  47. These data document for the first time that the expression of BMAL1, PER3, PPARD and CRY2 genes is altered in gestational diabetes compared to normal pregnant women. deranged expression of clock genes may play a pathogenic role in GDM. PMID: 23323702
  48. Studies indicate that in the cytoplasm, PER3 protein heterodimerizes with PER1, PER2, CRY1, and CRY2 proteins and enters into the nucleus, resulting in repression of CLOCK-BMAL1-mediated transcription. PMID: 23546644
  49. Cortisol secretion was modified among police officers with different PER3 VNTR clock gene variants. PMID: 23524621
  50. the association study of the 54-nucleotide repeat in exon 18 of the hPer3 gene with a predisposition to opioid dependence among residents of the West Siberian region of Russia PMID: 22976125

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Involvement in disease Advanced sleep phase syndrome, familial, 3 (FASPS3)
Subcellular Location Cytoplasm, Nucleus
Database Links

HGNC: 8847

OMIM: 603427

KEGG: hsa:8863

STRING: 9606.ENSP00000355031

UniGene: Hs.162200

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