PEX13 Antibody, FITC conjugated

Datasheet

Code	CSB-PA849799LC01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PEX13 Polyclonal antibody

Uniprot No.

Q92968

Target Names

PEX13

Alternative Names

2610008O20Rik antibody; NALD antibody; OTTMUSP00000005454 antibody; Peroxin 13 antibody; Peroxin-13 antibody; Peroxin13 antibody; Peroxisomal membrane protein PEX 13 antibody; Peroxisomal membrane protein PEX13 antibody; Peroxisome biogenesis factor 13 antibody; PEX 13 antibody; pex13 antibody; PEX13_HUMAN antibody; RP23-188K3.1 antibody; ZWS antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Peroxisomal membrane protein PEX13 protein (1-130AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Component of the peroxisomal translocation machinery with PEX14 and PEX17. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PAS10/PEX5). Involved in the import of PTS1 and PTS2 proteins.

Gene References into Functions

Data suggest that soluble/cytosolic PEX5 interacts with PEX14/PEX13 complex, a model for the docking/translocation module (DTM) of the peroxisomal matrix protein translocon; PEX14/PEX13 complex appears to function in peroxisomal membrane as large cavity into which cytosolic PEX5 can enter to release its cargo. (PEX = peroxisomal biogenesis factor) PMID: 28765278
our results demonstrate that PEX13 is required for selective autophagy, and suggest that dysregulation of PEX13-mediated mitophagy may contribute to ZSS pathogenesis. PMID: 27827795
Results show PEX13 interacts with itself in peroxisomes in living cells and the import of PTS1 (peroxisomal targeting signal 1) proteins is specifically disrupted when homooligomerization of PEX13 is interrupted. PMID: 23716570
Pex13p has a role in determining the peroxisomal localization of Pex14p PMID: 14715663
analysis of PEX13 substitution of Ile326 by threonine in a patient with peroxisomal biogenesis disorder [case report] PMID: 16006427
Zellweger syndrome caused by PEX13 deficiency: report of two novel mutations. PMID: 19449432

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Involvement in disease

Peroxisome biogenesis disorder complementation group 13 (PBD-CG13); Peroxisome biogenesis disorder 11A (PBD11A); Peroxisome biogenesis disorder 11B (PBD11B)

Subcellular Location

Peroxisome membrane; Single-pass membrane protein.

Protein Families

Peroxin-13 family

Database Links

HGNC: 8855

OMIM: 601789

KEGG: hsa:5194

STRING: 9606.ENSP00000295030

UniGene: Hs.161377

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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