PEX14 Antibody

Code CSB-PA017800ESR1HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
  • Immunohistochemistry of paraffin-embedded human liver cancer using CSB-PA017800ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA017800ESR1HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PEX14 Polyclonal antibody
Uniprot No. O75381
Target Names PEX14
Alternative Names dJ734G22.2 antibody; NAPP2 antibody; NF E2 associated polypeptide 2 antibody; Peroxin 14 antibody; Peroxin-14 antibody; Peroxisomal biogenesis factor 14 antibody; Peroxisomal membrane anchor protein PEX14 antibody; Peroxisomal membrane anchor protein Pex14p antibody; Peroxisomal membrane protein PEX14 antibody; pex14 antibody; PEX14_HUMAN antibody; Pex14p antibody; PTS1 receptor docking protein antibody; PTS1 receptor-docking protein antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Peroxisomal membrane protein PEX14 protein (118-377AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Data

Function Peroxisome membrane protein that is an essential component of the peroxisomal import machinery. Functions as a docking factor for the predominantly cytoplasmic PTS1 receptor (PEX5). Plays a key role for peroxisome movement through a direct interaction with tubulin.
Gene References into Functions
  1. data reveal subpopulations of peroxisomes showing only weak colocalization between PEX14 and PEX5 or PEX11 but at the same time a clear compartmentalized organization. This compartmentalization, which was less evident in cases of strong colocalization, indicates dynamic protein reorganization linked to changes occurring in the peroxisomes. PMID: 27311714
  2. PEX14 is the 13th PEX gene responsible for peroxisome biogenesis disorders. Thus far, only two patients with PEX14 deficiency have been reported. PMID: 26627464
  3. The novel Pex14-binding site may represent the initial tethering site of Pex5 from which the cargo-loaded receptor is further processed in a sequential manner. PMID: 24235149
  4. interaction of PEX5 with catalase and PEX14 PMID: 21976670
  5. PEX14 is a multi-tasking protein that not only facilitates peroxisomal protein import but is also required for peroxisome motility by serving as membrane anchor for microtubules. PMID: 21525035
  6. Serves as a transcriptional corepressor in addition to its peroxisomal function. PMID: 11863372
  7. peroxisomal localization of Pex14p is affected by Pex13p PMID: 14715663
  8. a new complementation group of the peroxisome biogenesis disorders with PEX14 as the defective gene PMID: 15146459
  9. This report represents the second PEX14-deficiency associated with Zellweger syndrome and the first documentation of a PEX14-deficient patient with detailed clinical follow-up and biochemical, morphological, and radiological data. PMID: 18285423
  10. N-terminal domain of Pex14, Pex14(N), adopts a three-helical fold. Pex5 and Pex19 ligand helices bind competitively to the same surface in Pex14(N) albeit with opposite directionality. PMID: 19197237
  11. analysis of the human Pex5.Pex14.PTS1 protein complex structure obtained by small angle X-ray scattering PMID: 19584060

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Involvement in disease Peroxisome biogenesis disorder complementation group K (PBD-CGK); Peroxisome biogenesis disorder 13A (PBD13A)
Subcellular Location Peroxisome membrane, Peripheral membrane protein, Cytoplasmic side
Protein Families Peroxin-14 family
Database Links

HGNC: 8856

OMIM: 601791

KEGG: hsa:5195

STRING: 9606.ENSP00000349016

UniGene: Hs.149983


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