PEX26 Antibody, Biotin conjugated

Code CSB-PA767196LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PEX26 Polyclonal antibody
Uniprot No.
Target Names
PEX26
Alternative Names
PEX26 antibody; Peroxisome assembly protein 26 antibody; Peroxin-26 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Peroxisome assembly protein 26 protein (1-159AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Probably required for protein import into peroxisomes. Anchors PEX1 and PEX6 to peroxisome membranes, possibly to form heteromeric AAA ATPase complexes required for the import of proteins into peroxisomes. Involved in the import of catalase and proteins containing a PTS2 target sequence, but not in import of proteins with a PTS1 target sequence.
Gene References into Functions
  1. In yeast, PEX26 follows the pathway that also ensures correct targeting of Pex15: PEX26 enters the endoplasmic reticulum (ER) in a GET-dependent and Pex19-independent manner. PMID: 26627908
  2. results suggested that peroxisome biogenesis requires Pex1p- and Pex6p-regulated dissociation of Pex14p from Pex26p PMID: 25016021
  3. PEX19 formed a complex with the peroxisomal tail anchored protein PEX26 in the cytosol and translocated it directly to peroxisomes by a TRC40-independent class I pathway. PMID: 23460677
  4. degree of temperature sensitivity in pex26 cell lines is predictive of the clinical phenotype in patients with PEX26 deficiency PMID: 12851857
  5. PEX26 deficiency impairs peroxisomal import of both PTS1- and PTS2-targeted matrix proteins. It undergoes alternative splicing to produce several splice forms, including PEX26-delta, which rescues peroxisome biogenesis in PEX26-deficient cells. PMID: 15858711
  6. Pex26p functions in recruiting to peroxisomes the complexes of the AAA ATPase peroxins. PMID: 16257970
  7. We analyzed targeting of human PEX26. Its C-terminal-targeting signal contains two binding sites for PEX19 and we conclude C-terminal PEX19-binding sites mark tail-anchored proteins for delivery to peroxisomes. PMID: 16763195
  8. the relative fraction of disease-causing alleles that occur in the coding and splice junction sequences of PEX26 gene. PMID: 19105186

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Involvement in disease
Peroxisome biogenesis disorder complementation group 8 (PBD-CG8); Peroxisome biogenesis disorder 7A (PBD7A); Peroxisome biogenesis disorder 7B (PBD7B)
Subcellular Location
Peroxisome membrane; Single-pass type II membrane protein.
Protein Families
Peroxin-26 family
Tissue Specificity
Widely expressed. Highly expressed in kidney, liver, brain and skeletal muscles. Expressed at intermediate level in pancreas, placenta and heart. Weakly expressed in lung.
Database Links

HGNC: 22965

OMIM: 608666

KEGG: hsa:55670

STRING: 9606.ENSP00000331106

UniGene: Hs.517400

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