PFKFB4 Antibody, FITC conjugated

1. PFKFB4 enhances the invasiveness of breast cancer cells in vitro and in vivo by inducing HA production and PFKFB4-induced expression of HAS2 depends upon the activation of p38 signaling. PMID: 30415245
2. findings suggest that the Warburg pathway enzyme PFKFB4 acts as a molecular fulcrum that couples sugar metabolism to transcriptional activation by stimulating SRC-3 to promote aggressive metastatic tumours PMID: 29615789
3. Data show that PFKFB4 is the target gene of PPARgamma which modulates the transcriptional activity of its promoter. PMID: 27769068
4. Our FD models could facilitate a better mechanistic understanding of FD and help develop effective therapeutics for FD and other fibrosis diseases. PMID: 27614159
5. High PFKFB4 expression is associated with colon and lung cancer. PMID: 28092678
6. HIF-1alpha transactivates hypoxia-responsive elements (HRE)-D of the promoter region of PFKFB4 in hypoxia condition. PMID: 27181362
7. Inhibition of PFKFB4 suppresses glycolysis and proliferation of multiple human cancer cell lines. PMID: 26221874
8. PFKFB4 suppresses oxidative stress and p62 accumulation, without which autophagy is stimulated likely as a ROS detoxification response. PMID: 25772235
9. Data indicate that the PFKFB4 expressed in multiple transformed cells and tumors functions to synthesize F2,6BP. PMID: 25115398
10. we found that the glycolytic enzyme PFKFB4 is essential for prostate cancer cell survival by maintaining the balance between the use of glucose for energy generation and the synthesis of antioxidants. PMID: 22576210
11. PFKFB4 has an important role in the progression of non-muscle-invasive bladder cancer ( PMID: 21396842
12. PFKFB4 and HO-2 are expressed in a coordinated manner to maintain glucose homeostasis. PMID: 22892400
13. Data suggest that molecular mechanism by which dihydrotestosterone induces Pfkfb4 (and thus glycolysis) during spermatogenesis involves stimulation of Sertoli cells to secrete FGF-2 (fibroblast growth factor 2); study uses recombinant human Pfkfb4. PMID: 22811469
14. an essential role of PFKFB4 in the maintenance of brain cancer stem-like cells PMID: 22056879
15. Sulforaphane is a potent inducer of apoptosis in hepatocellular carcinoma cells via PFKFB4-inhibition pathways. PMID: 21640852
16. Mechanisms of hypoxic regulation of PFKFB4 gene expression were studied in several cancer cell lines. PMID: 15474002
17. A detailed analysis of the 5'-flanking region of human gene pfkfb4 using different 5'-deletion promoter constructs was carried out; this gene is activated by serum and chemical hypoxia whereas beta-estradiol decreases its expression. PMID: 15642344
18. Overexpression of PFKFB-4 transcript levels in breast & colon malignant tumors correlates with enhanced expression of PFKFB-3, hypoxia-inducible factor(HIF)-1alpha & known HIF-1 dependent genes Glut1 & VEGF PMID: 15925437

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HGNC: 8875

OMIM: 605320

KEGG: hsa:5210

STRING: 9606.ENSP00000232375

UniGene: Hs.476217