PHF13 Antibody

Code CSB-PA017902LA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA017902LA01HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human adrenal gland tissue using CSB-PA017902LA01HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PHF13 Polyclonal antibody
Uniprot No.
Target Names
PHF13
Alternative Names
PHF13PHD finger protein 13 antibody; Survival time-associated PHD finger protein in ovarian cancer 1 antibody; SPOC1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human PHD finger protein 13 protein (1-300AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PHF13 Antibody (Product code: CSB-PA017902LA01HU) is Non-conjugated. For PHF13 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA017902LB01HU PHF13 Antibody, HRP conjugated ELISA
FITC CSB-PA017902LC01HU PHF13 Antibody, FITC conjugated
Biotin CSB-PA017902LD01HU PHF13 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Modulates chromatin structure. Required for normal chromosome condensation during the early stages of mitosis. Required for normal chromosome separation during mitosis.
Gene References into Functions
  1. High SPOC1 expression is associated with Cytomegalovirus infections. PMID: 29743358
  2. PHF13 has opposing effects throughout the HIV-1 replication cycle (figure 8). After viral entry and nuclear import of the PIC, PHF13 can increase the number of integrated HIV-1 proviral genomes. After integration, PHF13 acts as antiviral restriction factor and inhibits viral gene expression. PMID: 29021215
  3. These experiments showed that PHF13 binds specifically to DNA and to two types of histone H3 methyl tags (lysine 4-tri-methyl or lysine 4-di-methyl) where it functions as a transcriptional co-regulator. PMID: 27223324
  4. SPOC1-mediated restriction imposed upon Ad growth is relieved by its functional association with the Ad major core protein pVII that enters with the viral genome, followed by E1B-55K/E4orf6-dependent proteasomal degradation of SPOC1. PMID: 24278021
  5. SPOC1 modulates chromatin structure and that tight regulation of its expression levels and subcellular localization during mitosis are crucial for proper chromosome condensation and cell division. PMID: 19638409

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Subcellular Location
Nucleus. Nucleus, nucleoplasm. Note=Predominantly bound to chromatin, but a minor proportion is also detected in the nucleoplasm.
Database Links

HGNC: 22983

KEGG: hsa:148479

UniGene: Hs.516079

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