PHLDA2 Antibody

Code CSB-PA980478
Size US$297
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  • Immunohistochemistry analysis of paraffin-embedded human placenta tissue, using PHLA2 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PHLDA2 Polyclonal antibody
Uniprot No.
Target Names
PHLDA2
Alternative Names
Beckwith Wiedemann syndrome chromosome region 1 candidate protein C antibody; Beckwith-Wiedemann syndrome chromosomal region 1 candidate gene C protein antibody; BRW 1C antibody; BRW1C antibody; BWR 1C antibody; BWR1C antibody; HLDA 2 antibody; HLDA2 antibody; Imprinted in placenta and liver antibody; Imprinted in placenta and liver protein antibody; IPL antibody; p17 Beckwith Wiedemann region 1C antibody; p17 BWR1C antibody; p17-Beckwith-Wiedemann region 1 C antibody; p17-BWR1C antibody; PHLA2_HUMAN antibody; PHLDA 2 antibody; phlda2 antibody; Pleckstrin homology like domain family A member 2 antibody; Pleckstrin homology-like domain family A member 2 antibody; TSSC 3 antibody; Tumor suppressing STF cDNA 3 protein antibody; Tumor suppressing subchromosomal transferable fragment candidate gene 3 protein antibody; Tumor suppressing subchromosomal transferable fragment cDNA 3 antibody; Tumor suppressing subtransferable candidate 3 antibody; Tumor supressing STF cDNA 3 antibody; Tumor-suppressing STF cDNA 3 protein antibody; Tumor-suppressing subchromosomal transferable fragment candidate gene 3 protein antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from internal of Human PHLA2.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:50-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role in regulating placenta growth. May act via its PH domain that competes with other PH domain-containing proteins, thereby preventing their binding to membrane lipids.
Gene References into Functions
  1. PHLDA2 plays an important role in the occurrence and development of pregnancy complications by promoting trophoblast apoptosis and suppressing cell invasion. PMID: 26935516
  2. TSSC3 was a prognostic marker in osteosarcoma. PMID: 27044808
  3. TSSC3 downregulation promotes the Epithelial to mesenchymal transition (EMT) of osteosarcoma cells by regulating EMT markers via a signal transduction pathway that involves Snail, Wnt-beta-catenin/TCF, and GSK-3beta PMID: 26845447
  4. Placental PHLDA2 expression was significantly 2.3 fold higher in reduced fetal movements pregnancies resulting in delivery of a growth restricted compared with a normal birth weight infant. PMID: 26944942
  5. PHLDA2 may promote the occurrence/development of preeclampsia by inhibiting proliferation/migration/invasion of trophoblasts. PMID: 26218012
  6. The gene expression pattern of CDKN1C, H19, IGF2, KCNQ1 and PHLDA2 genes was evaluated using RT-PCR. PMID: 24986528
  7. elevated expression in placenta of growth restricted pregnancies [review] PMID: 24953163
  8. results suggest upregulated pleckstrin homology-like domain family A member 2 (PHLDA2) in placenta of monozygotic twins may be associated with the pathogenesis of singleton intrauterine growth restriction PMID: 24703004
  9. TSSC3 overexpression suppressed osteosarcoma cell growth and increased apoptosis through caspase-3 upregulation, suggesting that TSSC3 may play a pro-apoptosis role to maintain the normal balance of growth PMID: 24268429
  10. TSSC3 inhibits osteosarcoma tumorigenicity through reducing stemness and promoting apoptosis of tumor inducing cells PMID: 22610481
  11. A luciferase reporter assay was used to identify in the PHLDA2 promoter a 15 bp repeat sequence variant that significantly reduces PHLDA2-promoter efficiency. Maternal inheritance of the variant resulted in a significant increase in birth weight. PMID: 22444668
  12. The results suggest that placental PHLDA2 may provide a biomarker for suboptimal skeletal growth in pregnancies uncomplicated by overt fetal growth restriction. PMID: 22100507
  13. TSSC3 has a potent tumor suppressor role in osteosarcoma, probably by inhibition of growth and induction of apoptosis via the mitochondrial apoptosis pathway. PMID: 22021909
  14. PHLDA2 is a target gene of the BACH1 transcription factor according to ChIP-seq analysis in HEK 293 cells. PMID: 21555518
  15. Expression levels of PHLDA2 gene were upregulated in the first trimester pregnancy PMID: 20484977
  16. PHLDA2 gene is imprinted, with preferential expression from the maternal allele in placenta and liver. PMID: 9328465
  17. Transcripts of TSSC3 could not be detected in human oocytes and preimplantation embryos. PMID: 15952111
  18. Exposure of trophoblasts to hypoxia in vitro markedly reduced the expression of PHLDA2. PMID: 16584773
  19. association with low birth weight PMID: 17180344
  20. Up-regulation of TSSC3 occurred in Dicer knockdown cells. PMID: 17303335

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Subcellular Location
Cytoplasm. Membrane; Peripheral membrane protein.
Protein Families
PHLDA2 family
Tissue Specificity
Expressed in placenta and adult prostate gland. In placenta, it is present in all cells of the villous cytotrophoblast. The protein is absent in cells from hydatidiform moles. Hydatidiform mole is a gestation characterized by abnormal development of both
Database Links

HGNC: 12385

OMIM: 602131

KEGG: hsa:7262

STRING: 9606.ENSP00000319231

UniGene: Hs.154036

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