PHOX2A Antibody, HRP conjugated

1. PHOX2A expression is finely controlled during retinoic acid differentiation and this, together with PHOX2B down-regulation. PMID: 26902400
2. Genetic linkage was found at 11q13 between D11S4151 and D11S1320 and the PHOX2A gene. PMID: 22311481
3. Patients with ARIX and/or PHOX2B polymorphisms had less hypoplastic superior oblique muscles. PMID: 22170461
4. Mutations in the human ortholog of Aristaless cause X-linked mental retardation and epilepsy PMID: 11889467
5. The paired-like homeodomain protein, Arix, mediates protein kinase A-stimulated dopamine beta-hydroxylase gene transcription through its phosphorylation status PMID: 11943777
6. PHOX2A mutation analysis revealed a novel nonsense mutation in CFEOM2 (congenital fibrosis of extraocular muscles type 2) PMID: 14597037
7. the polymorphisms of the ARIX gene and PHOX2B gene may be genetic risk factors for the development of congenital superior oblique muscle palsy PMID: 16049556
8. PHOX2A, but not PHOX2B, seems to act directly on the c-RET promoter PMID: 16127999
9. Together, these results suggest that phosphorylation of Arix by ERK1/2 inhibits its ability to interact with target genes, and that both specificity of expression and modulation by external stimuli are monitored through the same transcription factor. PMID: 16156742
10. These results demonstrate the direct interactions of the Phox2a and b and dHAND transcription factors within a noradrenergic cell type PMID: 16280598
11. the alpha3 subunit is expressed in every terminally differentiated ganglionic cell, this is the first example of a "pan-autonomic" gene whose expression is regulated by PHOX2 proteins. PMID: 17344216
12. PHOX2A, like PHOX2B, is involved in the cascade leading to transcription factor TLX2 transactivation and presumably is involved in intestinal neuronal differentiation. PMID: 17505528
13. a variant of Secretogranin II has a role in regulation by PHOX2 transcription factors and in hypertension PMID: 17584765
14. The ARIX 153G>A polymorphism might be a genetic risk factor for the development of congenital superior oblique muscle palsy PMID: 18323871
15. PHOX2A and PHOX2B genes are highly co-expressed in human neuroblastoma. PMID: 18949361
16. PHOX2A gene, localized in a tumor suppressor candidate region at 11q, weas screened for mutations by DNA sequencing in 47 tumors of different stages. PMID: 19212675
17. Transfection of Phox2a cDNA significantly increases mRNA and protein levels of norepinephrine transporter and dopamine beta-hydroxylase. PMID: 19573018
18. Our 16-patient sample suggests that KIF21A and PHOX2A sequence variation does not have a role in common forms of congenital incomitant vertical strabismus. PMID: 19852579

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HGNC: 691

OMIM: 602078

KEGG: hsa:401

STRING: 9606.ENSP00000298231

UniGene: Hs.731115