PKD1L1 Antibody, HRP conjugated

Code CSB-PA823467LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PKD1L1 Polyclonal antibody
Uniprot No.
Target Names
PKD1L1
Alternative Names
PKD1L1 antibody; UNQ5785/PRO19563 antibody; Polycystic kidney disease protein 1-like 1 antibody; PC1-like 1 protein antibody; Polycystin-1L1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Polycystic kidney disease protein 1-like 1 protein (921-1164AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Component of a ciliary calcium channel that controls calcium concentration within primary cilia without affecting cytoplasmic calcium concentration. Forms a heterodimer with PKD2L1 in primary cilia and forms a calcium-permeant ciliary channel that regulates sonic hedgehog/SHH signaling and GLI2 transcription. Does not constitute the pore-forming subunit. Also involved in left/right axis specification downstream of nodal flow: forms a complex with PKD2 in cilia to facilitate flow detection in left/right patterning.
Gene References into Functions
  1. The authors report that the human PKD2-L1 selectivity filter is partially selective to calcium ions (Ca(2+)) moving into the cell, but blocked by high internal Ca(2+)concentrations, a unique feature of this transient receptor potential (TRP) channel family member. PMID: 27348301
  2. identification of bi-allelic PKD1L1 mutations recapitulates previous findings regarding phenotypic consequences of loss of function of the orthologous genes in mice and medaka fish and further expands our understanding of genetic contributions to laterality defects in humans PMID: 27616478
Involvement in disease
Heterotaxy, visceral, 8, autosomal (HTX8)
Subcellular Location
Cell projection, cilium membrane; Multi-pass membrane protein.
Protein Families
Polycystin family
Tissue Specificity
Detected in testis and in fetal and adult heart.
Database Links

HGNC: 18053

OMIM: 609721

KEGG: hsa:168507

STRING: 9606.ENSP00000289672

UniGene: Hs.195979

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