PLEK Antibody

Code CSB-PA018152LA01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PLEK Polyclonal antibody
Uniprot No.
Target Names
PLEK
Alternative Names
FLJ27168 antibody; OTTHUMP00000159962 antibody; p47 antibody; Platelet 47 kDa protein antibody; Platelet and leukocyte C kinase substrate antibody; Platelet P47 antibody; Platelet p47 protein antibody; Pleckstrin antibody; PLEK antibody; PLEK_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Pleckstrin protein (38-337AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The PLEK Antibody (Product code: CSB-PA018152LA01HU) is Non-conjugated. For PLEK Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA018152LB01HU PLEK Antibody, HRP conjugated ELISA
FITC CSB-PA018152LC01HU PLEK Antibody, FITC conjugated
Biotin CSB-PA018152LD01HU PLEK Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Major protein kinase C substrate of platelets.
Gene References into Functions
  1. Only one gene, pleckstrin , was significantly overexpressed in periodontitis,cardiovascular disease, rheumatoid arthritis and ulcerative colitis , implicating this gene as an important networking link between these chronic inflammatory diseases PMID: 26686060
  2. crystallization and preliminary X-ray diffraction analysis of the first 2 domains of pleckstrin (NPHDEP); work demonstrates that NPHDEP behaves as a monomer in solution and suggests that all 3 pleckstrin domains contribute to the dimerization interface PMID: 21393855
  3. Here they show that the PH domain from Bcr-Abl binds a number of proteins involved in vital cellular processes in leukemogenesis. PMID: 19944685
  4. Translocation requires its phosphorylation and newly formed ligands PMID: 12054651
  5. A pleckstrin homology domain located in G protein-coupled receptor kinase-2 (GRK2) residue 548 to 660 plays a significant role in mediating interaction between protein kinase C beta 1 and GRK2. PMID: 12456365
  6. The human pleckstrin-1 solution nuclear magnetic resonance structure of the C-terminal pleckstrin homology domain was reported. PMID: 15698571
  7. Proteins beta3 integrin, Vav3, Plekhm1, and Src, implicated in attachment defects, had normal exon sequences in a new type of osteopetrosis. PMID: 19546854
  8. Idirect associations between plek and actin through 17 beta-hydroxysteroid dehydrogenase 4, alpha-actinin, moesin, radixin and factor XIIIA, is proposed. PMID: 19722192

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Database Links

HGNC: 9070

OMIM: 173570

KEGG: hsa:5341

STRING: 9606.ENSP00000234313

UniGene: Hs.468840

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