Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PLEKHO1 Polyclonal antibody

Uniprot No.

Q53GL0

Target Names

PLEKHO1

Alternative Names

C-Jun-binding protein antibody; Casein kinase 2-interacting protein 1 antibody; CK2 interacting protein 1 antibody; CK2 interacting protein 1 HQ0024c protein antibody; CK2-interacting protein 1 antibody; CKIP 1 antibody; CKIP-1 antibody; CKIP1 antibody; JBP antibody; OC120 antibody; Osteoclast maturation associated gene 120 protein antibody; Osteoclast maturation-associated gene 120 protein antibody; PH domain-containing family O member 1 antibody; PKHO1_HUMAN antibody; Pleckstrin homology domain containing family O member 1 antibody; Pleckstrin homology domain-containing family O member 1 antibody; PLEKHO1 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Pleckstrin homology domain-containing family O member 1 protein (143-404AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

HRP

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

Plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein (CP). May function to target CK2 to the plasma membrane thereby serving as an adapter to facilitate the phosphorylation of CP by protein kinase 2 (CK2). Appears to target ATM to the plasma membrane. Appears to also inhibit tumor cell growth by inhibiting AKT-mediated cell-survival. Also implicated in PI3K-regulated muscle differentiation, the regulation of AP-1 activity (plasma membrane bound AP-1 regulator that translocates to the nucleus) and the promotion of apoptosis induced by tumor necrosis factor TNF. When bound to PKB, it inhibits it probably by decreasing PKB level of phosphorylation.

Gene References into Functions

we firstly revealed the association of CKIP-1 rs2306235 polymorphism with an increased risk of CHF in Chinese Han populations. PMID: 28402261
we provided the first line of evidence that CKIP-1 regulated megakaryocytic differentiation and CKIP-1 knockout mice showed defective megakaryopoiesis and platelet production, suggesting a novel role for CKIP-1 in hematopoietic differentiation. PMID: 28404913
these data integrated CKIP-1 expression and function as a novel transcriptional regulator of macrophage polarization. PMID: 28212865
the increased PLEKHO1 could suppress Smad-dependent BMP signaling to inhibit bone formation during aging. PMID: 28083909
High expression levels of CKIP1 were associated with the development of lung cancer, and that CKIP1 knockdown may block tumor cell growth mainly by promoting cell apoptosis. PMID: 25966172
New light on the molecular mechanism of cell adhesion-mediated drug resistance in Non-Hodgkin's Lymphoma (NHL) and targeting CKIP-1 may be a novel therapeutic target for NHL. PMID: 27840970
There is a major role of the CK2alpha-interacting protein CKIP-1 in activation of PAK1 for neoplastic prostate cells transformation. PMID: 26160174
CKIP-1 interacts with CARMA1 and has an inhibitory effect on PKCtheta;-CBM-NF-kappaB signaling. PMID: 24465689
CKIP-1 controlled Smurf1 expression in colon cancer PMID: 23995790
overexpression triggers classical monocyte activation and transactivation of the TNF promoter PMID: 23583459
CKIP-1, through its leucine zipper, interacts with the Rpt6 and mediates the Smurf1-Rpt6 interaction. PMID: 23032291
CKIP-1 is involved in various important signaling pathways, controlling cell growth, apoptosis, differentiation, cytoskeleton and bone formation--REVIEW PMID: 22878216
The N-terminal PH domain and C-terminal auto-inhibitory region of CKIP-1 coordinate to determine its subcellular localization and the nucleus-plasma membrane shuttling. PMID: 20171213
examination of CK2alpha for a region that mediates interactions with CKIP-1 revealed a putative HIKE domain; this motif by itself may not be sufficient to mediate interactions. PMID: 15254037
CKIP-1 plays a role in the regulation of the actin cytoskeleton through its interactions with actin capping protein. PMID: 15831458
Data provide evidence that ATM, a predominantly nuclear kinase, could be relocalized to the plasma membrane by CKIP-1. PMID: 16325375
CKIP-1 has a role in cell morphology that depends on its interaction with actin-capping protein PMID: 16987810
The results provide a novel role of CKIP-1 in cytokine signaling response and the biochemical mechanism, by which two previously identified modulators IFP35 and Nmi are involved via interactions. PMID: 17197158
Results indicate that CKIP-1, a novel Akt PH domain-interacting protein, would be a candidate of tumor suppressor with an Akt inhibitory function. PMID: 17942896
CKIP-1 is cleaved by caspase-3 during apoptosis. C-terminal fragments translocate to the cytoplasm and nucleus and inhibit AP-1 activity via direct interaction with c-Jun and JunD. CKIP-1 also forms a feedback with caspase-3 and enhances apoptosis. PMID: 15706351
CKIP-1 could interact with ATM and recruits nuclear ATM proteins partially to the plasma membrane. The results provide the first evidence that ATM, a predominantly nuclear kinase, could be re-localized to the plasma membrane. PMID: 16325375

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Subcellular Location

Cell membrane; Peripheral membrane protein. Nucleus. Cytoplasm.

Tissue Specificity

Abundantly expressed in skeletal muscle and heart, moderately in kidney, liver, brain and placenta and sparingly in the pancreas and lung. Easily detectable in cell lines such as MOLT-4, HEK293 and Jurkat.

Database Links

HGNC: 24310

OMIM: 608335

KEGG: hsa:51177

STRING: 9606.ENSP00000358120

UniGene: Hs.438824