PLXDC1 Antibody

Code CSB-PA548726
Size US$297
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  • Immunohistochemical analysis of paraffin-embedded human brain tissue using PLXDC1 antibody.
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PLXDC1 Polyclonal antibody
Uniprot No.
Target Names
PLXDC1
Alternative Names
DKFZp686F0937 antibody; FLJ36270 antibody; FLJ45632 antibody; OTTHUMP00000164240 antibody; Plexin domain containing 1 antibody; Plexin domain containing protein 1 precursor antibody; Plexin domain-containing protein 1 antibody; Plxdc1 antibody; PXDC1_HUMAN antibody; TEM3 antibody; TEM7 antibody; Tumor endothelial marker 3 antibody; Tumor endothelial marker 7 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Synthesized peptide derived from Internal of Human PLXDC1.
Immunogen Species
Homo sapiens (Human)
Clonality
Polyclonal
Purification Method
The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
Concentration
It differs from different batches. Please contact us to confirm it.
Form
Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 0.02% sodium azide and 50% glycerol.
Tested Applications
ELISA,IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:50-1:100
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a critical role in endothelial cell capillary morphogenesis.
Gene References into Functions
  1. PLXDC1 silencing by the HA-CH-NP/siRNA significantly inhibited tumor growth in A2780 tumor-bearing mice. PMID: 29890852
  2. Immunohistochemical analysis of 122 gliomas showed that TGLI1 expression was positively correlated with VEGF-C, TEM7 and microvessel density. PMID: 26093087
  3. PLXDC1 and PLXDC2 as the transmembrane receptors for the multifunctional factor PEDF. PMID: 25535841
  4. TEM-7 is a vascular protein associated with angiogenic states. TEM-7 is a novel and attractive target for antiangiogenic therapy. PMID: 21958527
  5. All osteosarcoma cell lines, 6/9 tumors but none of the bone specimens expressed mRNA of TEM7 secreted forms 1 and 2. PMID: 20032373
  6. TEM7 expression level closely parallels histology-based prognostication of OGS metastasis and, therefore, it is a therapeutic target. PMID: 17560052
  7. TEM7 may play significant role in proliferation and maintenance of neovascular endothelial cells in fibrovascular membranes. TEM7 may be molecular target for new diagnostic and therapeutic strategies for proliferative diabetic retinopathy. PMID: 18316703

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Subcellular Location
[Isoform 1]: Cell membrane; Single-pass type I membrane protein. Cell junction, tight junction. Note=Localized predominantly at the tight junctions of vascular endothelial cells and to a lesser extent at the luminal surface of vascular endothelial cells.; [Isoform 2]: Secreted.; [Isoform 3]: Secreted.; [Isoform 4]: Cytoplasm.
Protein Families
Plexin family
Tissue Specificity
Detected in endothelial cells from colorectal cancer, and in endothelial cells from primary cancers of the lung, liver, pancreas, breast and brain. Not detectable in endothelial cells from normal tissue. Expressed in fibrovascular membrane with increased
Database Links

HGNC: 20945

OMIM: 606826

KEGG: hsa:57125

STRING: 9606.ENSP00000323927

UniGene: Hs.125036

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