POLR1C Antibody, FITC conjugated

Datasheet

Code	CSB-PA018324LC01HU
Size	US$166
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) POLR1C Polyclonal antibody

Uniprot No.

O15160

Target Names

POLR1C

Alternative Names

40kDa antibody; AA409007 antibody; AA959927 antibody; Ac2-127 antibody; AC40 antibody; AL024089 antibody; DNA directed RNA polymerase I subunit C antibody; DNA directed RNA polymerases I and III 40 kDa polypeptide antibody; DNA directed RNA polymerases I and III subunit RPAC1 antibody; DNA-directed RNA polymerase I subunit C antibody; DNA-directed RNA polymerases I and III 40 kDa polypeptide antibody; DNA-directed RNA polymerases I and III subunit RPAC1 antibody; MGC105583 antibody; MGC161175 antibody; POLR1C antibody; POLR1E antibody; Polymerase (RNA) I polypeptide C, 30kDa antibody; RNA polymerase 1 1 antibody; RNA polymerase I subunit C antibody; RNA polymerases I and III subunit AC1 antibody; RP3-337H4.4 antibody; RPA39 antibody; RPA40 antibody; RPA5 antibody; RPAC1 antibody; RPAC1_HUMAN antibody; RPC40 antibody; Rpo1 1 antibody; TCS3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human DNA-directed RNA polymerases I and III subunit RPAC1 protein (125-230AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I and III which synthesize ribosomal RNA precursors and small RNAs, such as 5S rRNA and tRNAs, respectively. RPAC1 is part of the Pol core element with the central large cleft and probably a clamp element that moves to open and close the cleft.

Gene References into Functions

Treacher Collins syndrome 3-associated mutation leads to the localization of POLR1C into the lysosome and inhibits chondrogenic differentiation, possibly explaining a portion of the pathological molecular basis underlying Treacher Collins syndrome. PMID: 29567474
This study is the first to show that distinct mutations in a gene coding for a shared subunit of two RNA polymerases lead to selective modification of the enzymes' availability leading to two different clinical conditions. PMID: 26151409
Mutations in TCOF1, POLR1C and POLR1D have all been implicated in causing TCS PMID: 24690222
mutations in both alleles of POLR1C in three individuals with Treacher Collins syndrome. PMID: 21131976
analyzed the kinetics of assembly and elongation of the RNA polymerase I complex on endogenous ribosomal genes in the nuclei of living cells with the use of in vivo microscopy PMID: 12446911

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Involvement in disease

Treacher Collins syndrome 3 (TCS3); Leukodystrophy, hypomyelinating, 11 (HLD11)

Subcellular Location

Nucleus.

Protein Families

Archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family

Database Links

HGNC: 20194

OMIM: 248390

KEGG: hsa:9533

STRING: 9606.ENSP00000361465

UniGene: Hs.743509

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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