POLR2C Antibody, FITC conjugated

Datasheet

Code	CSB-PA018329LC01HU
Size	US$166
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) POLR2C Polyclonal antibody

Uniprot No.

P19387

Target Names

POLR2C

Alternative Names

DNA directed RNA polymerase II 33 kDa polypeptide antibody; DNA directed RNA polymerase II subunit C antibody; DNA directed RNA polymerase II subunit RPB3 antibody; DNA-directed RNA polymerase II 33 kDa polypeptide antibody; DNA-directed RNA polymerase II subunit C antibody; DNA-directed RNA polymerase II subunit RPB3 antibody; hRPB33 antibody; hsRPB3 antibody; POLR 2C antibody; POLR2 C antibody; Polr2c antibody; Polymerase (RNA) II (DNA directed) polypeptide C; 33kDa antibody; polymerase RNA II DNA directed polypeptide C 33kDa antibody; RNA polymerase II polypeptide C antibody; RNA polymerase II subunit 3 antibody; RNA polymerase II subunit B3 antibody; RPB 3 antibody; RPB3 antibody; RPB3_HUMAN antibody; RPB31 antibody; RPB33 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human DNA-directed RNA polymerase II subunit RPB3 protein (2-275AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

FITC

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB3 is part of the core element with the central large cleft and the clamp element that moves to open and close the cleft.

Gene References into Functions

FUS low-complexicity phase separates to recruit RNA polymerase II C-terminal domain in vitro. PMID: 26455390
These findings suggest that N-terminus of Rpb3 selectively inhibits Rpb3-high-expression hepatocellular carcinoma cells proliferation. N-terminus of Rpb3 may be useful in treating patients diagnosed with Rpb3-high-expression hepatocellular carcinoma. PMID: 25211001
eEF1gamma, in addition to its role in translation elongation complex, is involved in regulating Vimentin gene by contacting both pol II and the Vimentin promoter region and shuttling/nursing the Vimentin mRNA PMID: 21217813
interaction between RPB3 and ATF4 PMID: 12860379
Rpb3 is a potential nuclear target of insulin-like growth factor binding protein-3 PMID: 16455777

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Subcellular Location

Nucleus.

Protein Families

Archaeal RpoD/eukaryotic RPB3 RNA polymerase subunit family

Database Links

HGNC: 9189

OMIM: 180663

KEGG: hsa:5432

STRING: 9606.ENSP00000219252

UniGene: Hs.79402

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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