POU3F1 Antibody, FITC conjugated

Code CSB-PA018396LC01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) POU3F1 Polyclonal antibody
Uniprot No.
Target Names
POU3F1
Alternative Names
class 3 antibody; Oct-6 antibody; OCT6 antibody; Octamer-binding protein 6 antibody; Octamer-binding transcription factor 6 antibody; OTF-6 antibody; OTF6 antibody; PO3F1_HUMAN antibody; POU class 3 homeobox 1 antibody; POU domain antibody; POU domain class 3 transcription factor 1 antibody; POU domain transcription factor SCIP antibody; pou3f1 antibody; SCIP antibody; transcription factor 1 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human POU domain, class 3, transcription factor 1 protein (59-257AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Transcription factor that binds to the octamer motif (5'-ATTTGCAT-3'). Acts as a transcriptional activator when binding cooperatively with SOX4, SOX11, or SOX12 to gene promoters. Acts as a transcriptional repressor of myelin-specific genes.
Gene References into Functions
  1. Combined high OATP1A2/high OCT6 may be a potential predictor of response to anthracycline/taxane-based chemotherapy in breast cancer PMID: 24671357
  2. CpG island hypermethylation contributes to down-regulation of Oct-6 mRNA expression in hepatocellular carcinoma. PMID: 21448695
  3. Our results suggest that Tst-1 and Skn-1a regulate expression of MMPs in keratinocytes and effect both the expression and activation of these proteolytic enzymes. PMID: 17195013
  4. Strict control of Pou3f1 transgene expression is critical to proper myelination, and factors responsible for Pouf31 downregulation during myelination may play important roles in the development of peripheral neuropathies. PMID: 17959798
Subcellular Location
Nucleus.
Protein Families
POU transcription factor family, Class-3 subfamily
Tissue Specificity
Expressed in embryonal stem cells and in the developing brain.
Database Links

HGNC: 9214

OMIM: 602479

KEGG: hsa:5453

STRING: 9606.ENSP00000362103

UniGene: Hs.1837

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