PPP1R11 Antibody, FITC conjugated

Code CSB-PA03834C0Rb
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PPP1R11 Polyclonal antibody
Uniprot No.
Target Names
PPP1R11
Alternative Names
PPP1R11 antibody; HCGV antibody; TCTE5 antibody; E3 ubiquitin-protein ligase PPP1R11 antibody; EC 2.3.2.27 antibody; Hemochromatosis candidate gene V protein antibody; HCG V antibody; Protein phosphatase 1 regulatory subunit 11 antibody; Protein phosphatase inhibitor 3 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human E3 ubiquitin-protein ligase PPP1R11 protein (1-126AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
FITC
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Atypical E3 ubiquitin-protein ligase which ubiquitinates TLR2 at 'Lys-754' leading to its degradation by the proteasome. Plays a role in regulating inflammatory cytokine release and gram-positive bacterial clearance by functioning, in part, through the ubiquitination and degradation of TLR2. Inhibitor of protein phosphatase 1.
Gene References into Functions
  1. Lentiviral gene transfer or knockdown of PPP1R11 in mouse lungs significantly affects lung inflammation and the clearance of Staphylococcus aureus. There is a negative correlation between PPP1R11 and TLR2 levels in white blood cell samples isolated from patients with Staphylococcus aureus infections PMID: 27805901
  2. a model in which I3 regulates an SDS22-mediated PP1 activation step in solution that precedes SDS22 dissociation and transfer of PP1 to kinetochores, and which is required for PP1 to efficiently antagonize Aurora B. PMID: 25298395
  3. Sds22 and Inhibitor-3 form a heterotrimeric complex with PP1, both in cell lysates and after purification. A pool of PP1 is complexly controlled by both Sds22 and Inhibitor-3. PMID: 17630778
  4. inhibitor-3 is an in vivo target of caspase-3 and participates in the apoptotic response PMID: 18450750
  5. Inh3 has two domains that are required for its interaction with PP1. PMID: 18951879

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Tissue Specificity
Widely expressed.
Database Links

HGNC: 9285

OMIM: 606670

KEGG: hsa:6992

STRING: 9606.ENSP00000365963

UniGene: Hs.82887

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