PRUNE2 Antibody

Code CSB-PA848821DSR1HU
Size US$167Purchase it in Cusabio online store
(only available for customers from the US)
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  • Immunohistochemistry of paraffin-embedded human kidney tissue using CSB-PA848821DSR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human brain tissue using CSB-PA848821DSR1HU at dilution of 1:100

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Product Details

Full Product Name Rabbit anti-Homo sapiens (Human) PRUNE2 Polyclonal antibody
Uniprot No. Q8WUY3
Target Names PRUNE2
Alternative Names PRUNE2 antibody; BMCC1 antibody; BNIPXL antibody; C9orf65 antibody; KIAA0367 antibody; Protein prune homolog 2 antibody; BNIP2 motif-containing molecule at the C-terminal region 1 antibody
Raised in Rabbit
Species Reactivity Human
Immunogen Recombinant Human Protein prune homolog 2 protein (1-250AA)
Immunogen Species Homo sapiens (Human)
Conjugate Non-conjugated
Clonality Polyclonal
Isotype IgG
Purification Method Antigen Affinity Purified
Concentration It differs from different batches. Please contact us to confirm it.
Buffer PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form Liquid
Tested Applications ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Protocols ELISA Protocol
Immunohistochemistry (IHC) Protocol
Troubleshooting and FAQs Antibody FAQs
Storage Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
(From Uniprot)
May play an important role in regulating differentiation, survival and aggressiveness of the tumor cells.
Gene References into Functions
  1. E2F1 directly facilitated BMCC1 transcription. These results also suggest that BMCC1 induced by E2F1 acts as a tumor suppressor through its pro-apoptotic function, resulted in favorable prognosis of neuroblastoma. PMID: 27453342
  2. Results show prostate cancer antigen 3 (PCA3) as a dominant-negative oncogene and PRUNE2 protein as an unrecognized tumor suppressor gene in prostate cancer. PMID: 26080435
  3. BMCC1 negatively regulates phosphorylation pathway of AKT, resulted in apoptosis and the BNIP2 homology region of BMCC1 interacts with BCL2. PMID: 25611382
  4. recurrent germ line and somatic mutations in PRUNE2 were found in parathyroid carcinoma and computationally predicted to be deleterious; in addition, recurrent mutations in kinase genes related to cell migration and invasion were found. PMID: 25387265
  5. BMCC1 is an AP-2 associated endosomal protein in prostate cancer cells. PMID: 24040105
  6. We showed that Olfaxin, a novel Prune2 isoform contains a BCH motif and localizes predominantly to the synaptic cytosol in the olfactory bulb and layer Ia of the piriform cortex. PMID: 23059019
  7. PRUNE2 expression is correlated with the survival of leiomyosarcoma patients. Non-coding RNA PCA3 has a significant positive correlation with PRUNE2 and may play an important role in the pathogenesis of leiomyosarcoma. PMID: 22967466
  8. The nerve tissue-specific and post-development expression of PRUNE2/Prune2 suggests that PRUNE2 may contribute to the maintenance of mature nervous systems. PMID: 21234814
  9. BMCC1 is a new member of prognostic factors for NBL and may play an important role in regulating differentiation, survival and aggressiveness of the tumor cells PMID: 16288218
  10. Our results suggest that the caspase-mediated cleavage of BNIP-2 and BNIP-XL could result in the release of the BCH domain or smaller fragments that are crucial for their proapoptotic activities. PMID: 17961507
  11. findings show the BNIP2 & BCH domain of BNIPXL interacts with specific conformers of RhoA & mediates association with catalytic DH-PH domains of Lbc, a RhoA-specific guanine nucleotide exchange factor; BNIPXL inhibits Lbc-induced oncogenic transformation PMID: 18445682
  12. the longer BMCC1-1 isoform is upregulated in PCa tissues and metastases PMID: 19319183
  13. The androgen regulation of PRUNE2 expression in prostate cancer cells was found to not be of any diagnostic value. PMID: 19760627

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Subcellular Location Cytoplasm
Protein Families PPase class C family, Prune subfamily
Tissue Specificity A high level of expression seen in the nervous system (brain, cerebellum and spinal cord) as well as adrenal gland. Expressed at high levels in noneuroblastoma, rhabdomyosarcoma, melanoma and some osteosarcoma cell lines, whereas at only low levels in can
Database Links

HGNC: 25209

OMIM: 610691

KEGG: hsa:158471

STRING: 9606.ENSP00000365908

UniGene: Hs.262857

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