PSMA4 Antibody

Datasheet

Code	CSB-PA018869LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human pancreatic cancer using CSB-PA018869LA01HU at dilution of 1:100 Immunofluorescent analysis of A549 cells using CSB-PA018869LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
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Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PSMA4 Polyclonal antibody

Uniprot No.

P25789

Target Names

PSMA4

Alternative Names

HC9 antibody; HsT17706 antibody; Macropain subunit C9 antibody; MGC111191 antibody; MGC12467 antibody; MGC24813 antibody; Multicatalytic endopeptidase complex subunit C9 antibody; Proteasome (prosome macropain) subunit alpha type 4 antibody; Proteasome alpha 4 subunit antibody; Proteasome component C9 antibody; Proteasome subunit alpha type 4 antibody; Proteasome subunit alpha type-4 antibody; Proteasome subunit HC9 antibody; Proteasome subunit L antibody; PSA4_HUMAN antibody; PSC9 antibody; PSMA 4 antibody; psmA4 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Proteasome subunit alpha type-4 protein (148-184AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PSMA4 Antibody (Product code: CSB-PA018869LA01HU) is Non-conjugated. For PSMA4 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA018869LB01HU	PSMA4 Antibody, HRP conjugated	ELISA
FITC	CSB-PA018869LC01HU	PSMA4 Antibody, FITC conjugated
Biotin	CSB-PA018869LD01HU	PSMA4 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

Customer Reviews and Q&A

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Target Background

Function

Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).

Gene References into Functions

Five of these SNPs acted as cis-eQTLs, being associated with the transcription of IREB2 (rs2568494, rs16969968, rs11634351, rs6495309), PSMA4 (rs6495309) and ERCC1 (rs735482), out of 10,821 genes analyzed in lung. For these three genes, we obtained experimental evidence of differential allelic expression in lung tissue, pointing to the existence of in-cis genomic variants that regulate their transcription. PMID: 28181565
rs12901682 is associated with lung cancer risk in a Chinese Han population. PMID: 25744645
study concludes polymorphisms of TGM5, PPAP2B and PSMA4 are not major contributors tonon-small cell lung cancer susceptibility in never-smoking hinese population, this primarily can be attributed to the significantly distinct genetic background of Asian populations from western populations PMID: 24518713
Unexpected interaction between alpha4 and alpha7 subunits may provide a molecular basis for the formation of previously reported 13S and 16S assembly intermediates. PMID: 15225636
Parkin interacts with the proteasome subunit alpha4 PMID: 15987638

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Subcellular Location

Cytoplasm. Nucleus.

Protein Families

Peptidase T1A family

Database Links

HGNC: 9533

OMIM: 176846

KEGG: hsa:5685

STRING: 9606.ENSP00000044462

UniGene: Hs.251531

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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