PTGR1 Antibody

Datasheet

Code	CSB-PA018983LA01HU
Size	US$166
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Image	Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA018983LA01HU at dilution of 1:100 Immunofluorescent analysis of Hela cells using CSB-PA018983LA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)
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Product Details
Citations
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Customer Reviews and Q&A
Target Background

Product Details

Full Product Name

Rabbit anti-Homo sapiens (Human) PTGR1 Polyclonal antibody

Uniprot No.

Q14914

Target Names

PTGR1

Alternative Names

15-oxoprostaglandin 13-reductase antibody; FLJ99229 antibody; leukotriene B4 12-hydroxydehydrogenase antibody; LTB4DH antibody; MGC34943 antibody; NADP-dependent leukotriene B4 12-hydroxydehydrogenase antibody; PGR1 antibody; PRG-1 antibody; Prostaglandin reductase 1 antibody; Ptgr1 antibody; PTGR1_HUMAN antibody; RP11-16L21.1 antibody; ZADH3 antibody; zinc binding alcohol dehydrogenase domain containing 3 antibody

Raised in

Rabbit

Species Reactivity

Human

Immunogen

Recombinant Human Prostaglandin reductase 1 protein (202-282AA)

Immunogen Species

Homo sapiens (Human)

Conjugate

Non-conjugated

The PTGR1 Antibody (Product code: CSB-PA018983LA01HU) is Non-conjugated. For PTGR1 Antibody with conjugates, please check the following table.

Conjugate	Product Code	Product Name	Application
HRP	CSB-PA018983LB01HU	PTGR1 Antibody, HRP conjugated	ELISA
FITC	CSB-PA018983LC01HU	PTGR1 Antibody, FITC conjugated
Biotin	CSB-PA018983LD01HU	PTGR1 Antibody, Biotin conjugated	ELISA

Clonality

Polyclonal

Isotype

IgG

Purification Method

>95%, Protein G purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4

Form

Liquid

Tested Applications

ELISA, IHC, IF

Recommended Dilution

Application	Recommended Dilution
IHC	1:20-1:200
IF	1:50-1:200

Protocols

ELISA Protocol
Immunohistochemistry (IHC) Protocol
Immunofluorescence (IF) Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Citations

Quantitative Proteomic Analysis of Zearalenone-Induced Intestinal Damage in Weaned Piglets L Ma,Toxins,2022

Customer Reviews and Q&A

■ Customer Reviews

Average Rating:

5.0 - 1 reviews

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Applications : WB

Sample type: cells

Review: The relative abundance of proteins (APCS, PTGR1, FOLH1, EPRS, EEF2K, S100A16) between the control and ZEN groups analyzed by Western blot.

By Anonymous

Target Background

Function

NAD(P)H-dependent oxidoreductase involved in metabolic inactivation of pro- and anti-inflammatory eicosanoids: prostaglandins (PG), leukotrienes (LT) and lipoxins (LX). Catalyzes with high efficiency the reduction of the 13,14 double bond of 15-oxoPGs, including 15-oxo-PGE1, 15-oxo-PGE2, 15-oxo-PGF1-alpha and 15-oxo-PGF2-alpha. Catalyzes with lower efficiency the oxidation of the hydroxyl group at C12 of LTB4 and its derivatives, converting them into biologically less active 12-oxo-LTB4 metabolites. Reduces 15-oxo-LXA4 to 13,14 dihydro-15-oxo-LXA4, enhancing neutrophil recruitment at the inflammatory site. May play a role in metabolic detoxification of alkenals and ketones. Reduces alpha,beta-unsaturated alkenals and ketones, particularly those with medium-chain length, showing highest affinity toward (2E)-decenal and (3E)-3-nonen-2-one. May inactivate 4-hydroxy-2-nonenal, a cytotoxic lipid constituent of oxidized low-density lipoprotein particles.

Gene References into Functions

The data indicate that HMGB1-miR-522-3p-PTGR1 axis may be involved in the abnormal resolution of inflammation and suggest that this mechanism might be a target for modulation of chronic inflammatory disorder. PMID: 28088550
selenium had only a minor influence on prostaglandin reductase 1 (PTGR1) and NAD(P)H:quinone oxidoreductase 1 (NQO1) activity and protein levels PMID: 25179160
These results situate PtGR-1 as a critical modulator of both the steady state levels and signaling activities of fatty acid nitroalkenes in vivo. PMID: 23878198
Data show that two genes, LTB4DH and DPYSL3, were confirmed to be candidate genes for the predictor of a good immune response. PMID: 20804502
restoration of expression in enzyme-negative lung cancer cell lines induces apoptosis and growth inhibition PMID: 19595472

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Subcellular Location

Cytoplasm.

Protein Families

NADP-dependent oxidoreductase L4BD family

Tissue Specificity

High expression in the kidney, liver, and intestine but not in leukocytes.

Database Links

HGNC: 18429

OMIM: 601274

KEGG: hsa:22949

STRING: 9606.ENSP00000311572

UniGene: Hs.584864

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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