PTPRO Antibody

1. the present study demonstrated that PTPRO inhibits tumor growth in vitro and in vivo, indicating the tumor suppressive function of PTPRO in LSCC. This study highlights PTPRO as an epigenetically silenced gene, and a candidate tumor-suppressor of LSCC. PMID: 28586036
2. Single nucleotide polymorphism in PTPRO gene is associated with Acute Renal Graft Rejection. PMID: 27272414
3. Results provide evidence that PTPRO inhibits ERBB2-driven breast cancer through dephosphorylation leading to dual effects of ERBB2 signaling suppression and endosomal internalization of ERBB2. PMID: 27345410
4. PTPRO is a novel candidate gene in emphysema with severe airflow obstruction. PMID: 28199135
5. PTPRO truncated serves as an important tumor suppressor in hepatocellular carcinoma microenvironment. PMID: 26117839
6. These observations confirm that PTPRO plays a critical role in liver fibrogenesis by affecting PDGF signaling in HSC activation and might be developed into a feasible therapeutic approach for the treatment of chronic fibrotic liver diseases. PMID: 25633279
7. The optimal pH value of PTP-oc is approximately 7.0. PMID: 25462809
8. Loss of PTPRO expression is associated with chronic lymphocytic leukemia. PMID: 25482129
9. Results highlight the PTPRO contribution in negative regulation of SRC/EGFR signaling in colon cancer. PMID: 25301722
10. PTPRO was drastically decreased in fulminant hepatitis, and this was associated with enhanced beta-catenin accumulation but reduced IFN-gamma secretion. PMID: 25339662
11. Our study suggests an interesting PTPRO/TLR4/NF-kappaB signaling feedback loop in Hhepatocellular carcinomcarcinogenesis and progression PMID: 25034527
12. PTPRO level was decreased in the early phase but reversed in the late phase of hepatic ischemia reperfusion injury. PMID: 24128416
13. PTPRO methylation is associated with poor survival only in HER2-positive patients. PMID: 24090193
14. methylation and downregulation of PTPRO in a subset of primary human HCC and establish VCP as a novel functionally important substrate of this tyrosine phosphatase that could be a potential molecular target for HCC therapy. PMID: 23533167
15. ErbB2 is a direct substrate of PTPRO and decreased expression of PTPRO predicts poor prognosis for ErbB2-positive breast cancer patients. PMID: 22851698
16. Three intronic SNPs in PTPRO were associated with learning and memory. PMID: 22126837
17. hypermethylated PTPRO occurs frequently in esophageal squamous cell carcinoma PMID: 22099875
18. These findings further substantiate the role of TCL1 in PTPROt suppression and its importance in the pathogenesis of chronic lymphocytic leukemia. PMID: 22001392
19. The present study introduces mutations in PTPRO as another cause of autosomal-recessive nephrotic syndrome. PMID: 21722858
20. conclude that an intronic promoter within the protein tyrosine phosphatase, receptor type(GLEPP1) gene drives the expression of the protein tyrosine phosphatase-osteoclast(PTP) in a cell type-specific manner PMID: 12949066
21. Growth-suppressor characteristics of PTPRO are unique to a classical tumor suppressor in lung cancer. PMID: 15356345
22. overexpression of PTPROt inhibited BCR-triggered SYK tyrosyl phosphorylation, activation of the associated adaptor proteins SHC and BLNK, and downstream signaling events, and inhibition lymphoma cell proliferation and inducion of lymphoma cell apoptosis PMID: 16888096
23. PTPRO methylation and silencing has a role in chronic lymphocytic leukemia tumorigenesis PMID: 17545520
24. GLEPP1 expression may be a useful marker of podocyte injury in immunoglobulin A nephropathy, and may be predictive of clinical and pathological severity PMID: 17593862
25. PTPRO gene is co-regulated by both E2F1 and miR-17-92. PMID: 18644370
26. These data suggest that estrogen-mediated suppression of PTPRO is probably one of the early events in estrogen-induced tumorigenesis and that expression of PTPRO could facilitate endocrine therapy of breast cancer. PMID: 19095770
27. Dimerization of neuronal type III receptor-protein tyrosine phosphatase PTPRO in living cells is regulated by disulfide linkages in the PTPRO intracellular domain. PMID: 19573017
28. BCL6 repressed PTPROt transcription via a direct interaction with functional BCL6 binding sites in the PTPROt promoter PMID: 19855081

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HGNC: 9678

OMIM: 600579

KEGG: hsa:5800

STRING: 9606.ENSP00000281171

UniGene: Hs.160871