PTPRO Antibody

Code CSB-PA623099ESR2HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human skeletal muscle tissue using CSB-PA623099ESR2HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human pancreatic tissue using CSB-PA623099ESR2HU at dilution of 1:100

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) PTPRO Polyclonal antibody
Uniprot No.
Target Names
PTPRO
Alternative Names
FMI antibody; GLEPP 1 antibody; Glomerular epithelial protein 1 antibody; hPTP-J antibody; Pancreatic carcinoma phosphatase 2 antibody; PCP-2 antibody; PCP2 antibody; Phosphotyrosine phosphatase U2 antibody; Protein tyrosine phosphatase PTP U2 antibody; Protein tyrosine phosphatase PTPU2 antibody; Protein tyrosine phosphatase receptor type O antibody; Protein tyrosine phosphatase U2 antibody; Protein-tyrosine phosphatase J antibody; Protein-tyrosine phosphatase pi antibody; Protein-tyrosine phosphatase receptor omicron antibody; PTP pi antibody; PTP U2 antibody; PTP-J antibody; PTP-RO antibody; PTP-U2 antibody; PTPase U2 antibody; PTPRO antibody; PTPRO_HUMAN antibody; PTPROt antibody; PTPU 2 antibody; PTPU2 antibody; R-PTP-O antibody; R-PTP-psi antibody; Receptor type protein tyrosine phosphatase O antibody; Receptor type tyrosine protein phosphatase O antibody; Receptor-type protein-tyrosine phosphatase psi antibody; Receptor-type tyrosine-protein phosphatase O antibody; Receptor-type tyrosine-protein phosphatase U antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Receptor-type tyrosine-protein phosphatase O protein (30-300AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Possesses tyrosine phosphatase activity. Plays a role in regulating the glomerular pressure/filtration rate relationship through an effect on podocyte structure and function.
Gene References into Functions
  1. the present study demonstrated that PTPRO inhibits tumor growth in vitro and in vivo, indicating the tumor suppressive function of PTPRO in LSCC. This study highlights PTPRO as an epigenetically silenced gene, and a candidate tumor-suppressor of LSCC. PMID: 28586036
  2. Single nucleotide polymorphism in PTPRO gene is associated with Acute Renal Graft Rejection. PMID: 27272414
  3. Results provide evidence that PTPRO inhibits ERBB2-driven breast cancer through dephosphorylation leading to dual effects of ERBB2 signaling suppression and endosomal internalization of ERBB2. PMID: 27345410
  4. PTPRO is a novel candidate gene in emphysema with severe airflow obstruction. PMID: 28199135
  5. PTPRO truncated serves as an important tumor suppressor in hepatocellular carcinoma microenvironment. PMID: 26117839
  6. These observations confirm that PTPRO plays a critical role in liver fibrogenesis by affecting PDGF signaling in HSC activation and might be developed into a feasible therapeutic approach for the treatment of chronic fibrotic liver diseases. PMID: 25633279
  7. The optimal pH value of PTP-oc is approximately 7.0. PMID: 25462809
  8. Loss of PTPRO expression is associated with chronic lymphocytic leukemia. PMID: 25482129
  9. Results highlight the PTPRO contribution in negative regulation of SRC/EGFR signaling in colon cancer. PMID: 25301722
  10. PTPRO was drastically decreased in fulminant hepatitis, and this was associated with enhanced beta-catenin accumulation but reduced IFN-gamma secretion. PMID: 25339662
  11. Our study suggests an interesting PTPRO/TLR4/NF-kappaB signaling feedback loop in Hhepatocellular carcinomcarcinogenesis and progression PMID: 25034527
  12. PTPRO level was decreased in the early phase but reversed in the late phase of hepatic ischemia reperfusion injury. PMID: 24128416
  13. PTPRO methylation is associated with poor survival only in HER2-positive patients. PMID: 24090193
  14. methylation and downregulation of PTPRO in a subset of primary human HCC and establish VCP as a novel functionally important substrate of this tyrosine phosphatase that could be a potential molecular target for HCC therapy. PMID: 23533167
  15. ErbB2 is a direct substrate of PTPRO and decreased expression of PTPRO predicts poor prognosis for ErbB2-positive breast cancer patients. PMID: 22851698
  16. Three intronic SNPs in PTPRO were associated with learning and memory. PMID: 22126837
  17. hypermethylated PTPRO occurs frequently in esophageal squamous cell carcinoma PMID: 22099875
  18. These findings further substantiate the role of TCL1 in PTPROt suppression and its importance in the pathogenesis of chronic lymphocytic leukemia. PMID: 22001392
  19. The present study introduces mutations in PTPRO as another cause of autosomal-recessive nephrotic syndrome. PMID: 21722858
  20. conclude that an intronic promoter within the protein tyrosine phosphatase, receptor type(GLEPP1) gene drives the expression of the protein tyrosine phosphatase-osteoclast(PTP) in a cell type-specific manner PMID: 12949066
  21. Growth-suppressor characteristics of PTPRO are unique to a classical tumor suppressor in lung cancer. PMID: 15356345
  22. overexpression of PTPROt inhibited BCR-triggered SYK tyrosyl phosphorylation, activation of the associated adaptor proteins SHC and BLNK, and downstream signaling events, and inhibition lymphoma cell proliferation and inducion of lymphoma cell apoptosis PMID: 16888096
  23. PTPRO methylation and silencing has a role in chronic lymphocytic leukemia tumorigenesis PMID: 17545520
  24. GLEPP1 expression may be a useful marker of podocyte injury in immunoglobulin A nephropathy, and may be predictive of clinical and pathological severity PMID: 17593862
  25. PTPRO gene is co-regulated by both E2F1 and miR-17-92. PMID: 18644370
  26. These data suggest that estrogen-mediated suppression of PTPRO is probably one of the early events in estrogen-induced tumorigenesis and that expression of PTPRO could facilitate endocrine therapy of breast cancer. PMID: 19095770
  27. Dimerization of neuronal type III receptor-protein tyrosine phosphatase PTPRO in living cells is regulated by disulfide linkages in the PTPRO intracellular domain. PMID: 19573017
  28. BCL6 repressed PTPROt transcription via a direct interaction with functional BCL6 binding sites in the PTPROt promoter PMID: 19855081

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Involvement in disease
Nephrotic syndrome 6 (NPHS6)
Subcellular Location
Membrane; Single-pass type I membrane protein.
Protein Families
Protein-tyrosine phosphatase family, Receptor class 3 subfamily
Tissue Specificity
Glomerulus of kidney. Also detected in brain, lung and placenta.
Database Links

HGNC: 9678

OMIM: 600579

KEGG: hsa:5800

STRING: 9606.ENSP00000281171

UniGene: Hs.160871

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7505 Fannin St., Ste 610, Room 322 (CUBIO Innovation Center), Houston, TX 77054, USA
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