Phospho-ELK3 (S357) Antibody

1. Decreased Net expression characterize on-small-cell lung cancer progression. PMID: 19483189
2. Net might play an important role in pancreatic carcinogenesis PMID: 23469073
3. These results suggest that the ELK3-GATA3 axis is a major pathway that promotes metastasis of breast cancer MDA-MB-231 cells PMID: 27556500
4. The expression levels of Elk-3 in liver cirrhosis tissues were significantly higher than those in chronic hepatitis tissues. PMID: 27538444
5. We revealed that activation of the PI3K/Akt pathway was the main cause of impaired autophagy in ELK3 KD. Our results suggest that targeting ELK3 may be a potential approach to overcome doxorubicin resistance in breast cancer therapeutics. PMID: 27301639
6. Taken together, we suggest that ELK3 is an upstream regulator of the NF-kappaB signaling pathway, the inhibition of which leads to the suppression of peritumoral lymphatic vessel development, possibly due to a low VEGFC expression. PMID: 28188790
7. High expression of ELK3 is associated with migration and invasion of liver cancer stem cells. PMID: 27959451
8. results suggest that ELK3 plays a positive role in the metastasis of BC cells by indirectly regulating MT1-MMP expression PMID: 26637400
9. The oncogenic MicroRNA Hsa-miR-155-5p targets the transcription factor ELK3 and links it to the hypoxia response. PMID: 25401928
10. ELK3 plays a negative role of VEGF-induced angiogenesis through indirectly inhibiting ETS-1 function. PMID: 24719561
11. Net and HIF1alpha are components of distinct signaling pathways that are intricately linked PMID: 20427288
12. the Ras-Net (Elk-3) pathway involves microtubules and is inhibited by pyrazoles PMID: 18316589
13. These findings suggested that loss of Net repression could augment c-fos expression and further trigger neoplastic cell proliferation, which was involved in the pathogenesis of pancreatic cancer. PMID: 18832796

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HGNC: 3325

OMIM: 600247

KEGG: hsa:2004

STRING: 9606.ENSP00000228741

UniGene: Hs.46523