Phospho-SGOL1 (S14) Antibody

1. Aurora B kinase interacts with and phosphorylates Sgo1. Aurora B-mediated phosphorylation of Sgo1 regulates the distribution of Sgo1 between centromeres and chromosome arms. PMID: 25451264
2. SGOL1 variant B induces abnormal mitosis and resistance to taxane in non-small cell lung cancers. PMID: 24146025
3. Cohesin complex is shown to be a target of the prophase pathway at centrosomes and protected by Sgo1-dependent PP2A recruitment. PMID: 26365192
4. Sgo1 co-recruits Aurora B and PP2A to centromeres of unattached chromosomes. PMID: 25892238
5. Data indicate essential role of shugoshin-like protein 1 (Sgo1) in the maintenance of a proper mitotic progression in hepatoma cells and suggest that Sgo1 is a promising oncotarget for hepatocellular carcinoma (HCC). PMID: 25638162
6. Results show that Sgo1 is first recruited to kinetochores by H2A-pT120, and the kinetochore-bound Sgo1 is released by centromeric transcription. PMID: 26190260
7. Mutations in SGOL1 cause a novel cohesinopathy affecting heart and gut rhythm. PMID: 25282101
8. Bub1-mediated H2A phosphorylation penetrates kinetochores and that this histone mark contributes to a tension-sensitive Sgo1-based molecular switch for chromosome segregation. PMID: 24055156
9. The most significant association with MaxDrinks was observed with SNP rs11128951 (p = 4.27 x 10(-8)) near SGOL1 gene at 3p24.3. PMID: 23953852
10. Frameshift mutations of SGOL1 and PDS5B and the loss of their expression may be a feature of gastric and colorectal cancers with high microsatellite instability. PMID: 23850494
11. SGO1 promotes multidrug resistance of gastric cancer cells and may be useful as a novel therapeutic target for preventing or reversing multidrug resistance PMID: 23564482
12. Lentivirus-mediated siRNA interference targeting SGO-1 inhibits human NSCLC cell growth PMID: 22161216
13. These results suggest that SGOL1-P1 may function as a negative factor to native SGOL1, and that abundant expression of SGOL1-P1 may be responsible for chromosomal instability. PMID: 21532624
14. HP1alpha binding by INCENP or Shugoshin 1 (Sgo1) is dispensable for centromeric cohesion protection during mitosis of human cells, but might regulate yet unknown interphase functions of the chromosome passenger complex (CPC) or Sgo1 at the centromeres. PMID: 21346195
15. Data show that human germinal center-associated nuclear protein (GANP) is critically involved in cell proliferation at the mitotic phase through its selective support of shugoshin-1 mRNA export. PMID: 20384790
16. Bub1 protects centromeric cohesion through Shugoshin in mitosis PMID: 15604152
17. A shugoshin-like protein associates with centromeres during prophase and disappears at the onset of anaphase PMID: 15737064
18. a specific subtype of serine/threonine protein phosphatase 2A (PP2A) associates with human shugoshin PMID: 16541025
19. Bub1 targets PP2A to centromeres, which in turn maintains Sgo1 at centromeres by counteracting Plk1-mediated chromosome removal of Sgo1. PMID: 16580887
20. depletion of Sgo1 results in precocious chromosomal segregation and massive mitotic arrest PMID: 16628005
21. Mutation in the SGOL1 D-box causes transient metaphase arrest, and leads to defects in chromosome alignment and segregation. PMID: 17448445
22. Shugoshin 1 plays a central role in kinetochore assembly and is required for kinetochore targeting of Plk1. PMID: 17617734
23. Results suggest that NEK2A-mediated phosphorylation of Sgo1 (SGOL1) provides a link between centromeric cohesion and spindle microtubule attachment at the kinetochores. PMID: 17621308
24. Centriole splitting induced by Sgo1 depletion or expression of a dominant negative mutant is suppressed by ectopic expression of sSgo1 or by Plk1 knockdown. PMID: 18331714
25. findings suggest that hSgo1-downregulated colorectal cancers have a clinicopathological character of chromosome instability (CIN), and hSgo1 downregulation leads to CIN in colorectal cancer cells. PMID: 18635744
26. the direct link between HP1 and shugoshin is conserved in human cells PMID: 18716626
27. the spindle checkpoint kinase Bub1 contributes to the maintenance of Sgo1 steady-state protein levels in an APC/C-independent mechanism. PMID: 19015261
28. Report structure and function of the PP2A-shugoshin interaction. PMID: 19716788
29. A comprehensive review of Sgo1 function in eukaryote at meiosis and mitosis. PMID: 16112668

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HGNC: 25088

OMIM: 609168

KEGG: hsa:151648

STRING: 9606.ENSP00000263753

UniGene: Hs.105153