RANBP1 Antibody

Code CSB-PA019308HA01HU
Size US$166
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  • Immunohistochemistry of paraffin-embedded human liver tissue using CSB-PA019308HA01HU at dilution of 1:100

  • Immunofluorescent analysis of Hela cells using CSB-PA019308HA01HU at dilution of 1:100 and Alexa Fluor 488-congugated AffiniPure Goat Anti-Rabbit IgG(H+L)

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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RANBP1 Polyclonal antibody
Uniprot No.
Target Names
RANBP1
Alternative Names
HTF9A antibody; RAN binding protein 1 antibody; Ran specific GTPase activating protein antibody; Ran-binding protein 1 antibody; Ran-specific GTPase-activating protein antibody; RANBP1 antibody; RANG_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ran-specific GTPase-activating protein (52-111AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The RANBP1 Antibody (Product code: CSB-PA019308HA01HU) is Non-conjugated. For RANBP1 Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA019308HB01HU RANBP1 Antibody, HRP conjugated ELISA
FITC CSB-PA019308HC01HU RANBP1 Antibody, FITC conjugated
Biotin CSB-PA019308HD01HU RANBP1 Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA, IHC, IF
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
IF 1:50-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Plays a role in RAN-dependent nucleocytoplasmic transport. Alleviates the TNPO1-dependent inhibition of RAN GTPase activity and mediates the dissociation of RAN from proteins involved in transport into the nucleus. Induces a conformation change in the complex formed by XPO1 and RAN that triggers the release of the nuclear export signal of cargo proteins. Promotes the disassembly of the complex formed by RAN and importin beta. Promotes dissociation of RAN from a complex with KPNA2 and CSE1L. Required for normal mitotic spindle assembly and normal progress through mitosis via its effect on RAN. Does not increase the RAN GTPase activity by itself, but increases GTP hydrolysis mediated by RANGAP1. Inhibits RCC1-dependent exchange of RAN-bound GDP by GTP.
Gene References into Functions
  1. Sgk1-dependent regulation of RANBP1 has functional consequences on both mitotic microtubule activity and taxol sensitivity of cancer cells. PMID: 23108393
  2. RANBP1 on 22q11.21 locus might be causally related to the smooth pursuit eye movement abnormality rather than the development of schizophrenia. PMID: 21184585
  3. These data indicate that RANBP1 activity is required for the proper localization of specific factors that regulate microtubule function; loss of this activity contributes to the generation of aneuploidy in a microtubule-dependent manner. PMID: 17940066
  4. RanBP1-interfered cells show an increased apoptotic response to taxol compared to their counterpart with normal or high RanBP1 levels, and this response is caspase-3 dependent. PMID: 19270727
  5. Generation of Ran-GTP from Ran-GDP by importin-beta is activated by Ran-binding protein-1 (RanBP1) that forms a trimeric complex with Ran-GDP and importin-beta. PMID: 19549784

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Protein Families
RANBP1 family
Database Links

HGNC: 9847

OMIM: 601180

KEGG: hsa:5902

STRING: 9606.ENSP00000327583

UniGene: Hs.24763

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