RARS Antibody

Datasheet

Code	CSB-PA019344GA01HU
Size	$600
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Product Details
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Customer Reviews and Q&A
Target Background

Product Details

Uniprot No.

P54136

Target Names

RARS

Alternative Names

2610011N19Rik antibody; 2610037E21Rik antibody; AL033339 antibody; Arginine tRNA ligase 1, cytoplasmic antibody; Arginine tRNA ligase antibody; Arginine--tRNA ligase antibody; Arginyl tRNA synthetase 1 antibody; Arginyl tRNA synthetase cytoplasmic antibody; Arginyl tRNA synthetase, cytoplasmic antibody; Arginyl-tRNA synthetase, cytoplasmic antibody; ArgRS antibody; AW985894 antibody; DALRD 1 antibody; DALRD1 antibody; EC 6.1.1.19 antibody; MGC8641 antibody; MGC86730 antibody; RARS antibody; SYRC_HUMAN antibody; wu:fa96g09 antibody; zgc:56050 antibody; zgc:86730 antibody

Species Reactivity

Human,Mouse,Rat

Immunogen

Human RARS

Immunogen Species

Homo sapiens (Human)

Isotype

IgG

Purification Method

Antigen Affinity purified

Concentration

It differs from different batches. Please contact us to confirm it.

Buffer

PBS with 0.02% Sodium Azide, 50% Glycerol, pH 7.3. -20°C, Avoid freeze / thaw cycles.

Tested Applications

ELISA

Protocols

ELISA Protocol

Troubleshooting and FAQs

Antibody FAQs

Storage

Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Lead Time

Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Usage

For Research Use Only. Not for use in diagnostic or therapeutic procedures.

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Target Background

Function

Forms part of a macromolecular complex that catalyzes the attachment of specific amino acids to cognate tRNAs during protein synthesis. Modulates the secretion of AIMP1 and may be involved in generation of the inflammatory cytokine EMAP2 from AIMP1.

Gene References into Functions

Missense variant Ser456Leu and a de novo deletion Tyr616Leufs*6 cause disorder akin to Pelizaeus-Merzbacher disease. PMID: 28905880
Data indicate that the N terminus of Pro-EMAP II binds to its C terminus, arginyl-tRNA synthetase, and the neurofilament light subunit. PMID: 25724651
The mRNA of human cytoplasmic arginyl-tRNA synthetase recruits prokaryotic ribosomes independently. PMID: 24898251
report describe 4 patients with hypomyelination and mutations in RARS PMID: 24777941
The crystal structures of the L-arginine-complexed, and L-canavanine-complexed forms of arginyl-tRNA synthetase from Homo sapiens. PMID: 24859084
Hemin binds to human cytoplasmic arginyl-tRNA synthetase and inhibits its catalytic activity PMID: 20923763
leucyl-tRNA synthetase requires its C-terminal domain for its interaction with arginyl-tRNA synthetase in the multi-tRNA synthetase complex PMID: 16055448
RARS over-expression impairs aminoacyl t-RNA synthetase interacting multifunctional protein (AIMP1) secretion by both HeLa and MCF7 cells. PMID: 17443684

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Involvement in disease

Leukodystrophy, hypomyelinating, 9 (HLD9)

Subcellular Location

Cytoplasm. Cytoplasm, cytosol.

Protein Families

Class-I aminoacyl-tRNA synthetase family

Database Links

HGNC: 9870

OMIM: 107820

KEGG: hsa:5917

STRING: 9606.ENSP00000231572

UniGene: Hs.654907

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Antibody FAQs What Is an Antibody? How to Choose an Antibody for Scientific Research? The difference between primary antibody and secondary antibod The Meaning of Irregular Antibody Screening Tag Antibodies, Your Good Partner in Protein Research How to Choose the Loading Control Antibodies?

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301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)

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Address

7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA

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