RASAL1 Antibody

1. Domain topology of human Rasal PMID: 28885980
2. HIF1alpha and transforming growth factor (TGF)/SMAD signalling pathways synergistically regulate hypoxia-induced endothelial-to-mesenchymal transition through both DNMT3a-mediated hypermethylation of RASAL1 promoter and direct SNAIL induction. PMID: 27012941
3. RASAL1 role in in sorafenib-resistance of liver cancer cells PMID: 27878301
4. our study showed significantly longer overall survival times for oesophagogastric adenocarcinoma patients without RASAL1 expression PMID: 28011578
5. DNA methylation, TGFbeta1 and RASAL1 appear to have an interacting relationship. PMID: 27124111
6. Report a new subtype of high-grade mandibular osteosarcoma with RASAL1/MDM2 amplification. PMID: 26997440
7. These findings suggest that Ebp1 suppressed thyroid cancer cell lines by upregulating RASRAL expression. PMID: 26008146
8. large chromosome 12 rearrangement, spanning MDM2 and RASAL1, is the first recurrent molecular abnormality to be reported in juvenile ossifying fibroma PMID: 24925056
9. Loss of RASAL1 expression is associated with gastric carcinogenesis. PMID: 25735335
10. Transcriptional suppression of RASAL1 through aberrant promoter methylation contributes to endothelial-mesenchymal transition and ultimately to progression of cardiac fibrosis. PMID: 25616414
11. Promoter hypermethylation of the RASAL1 gene was detected in MKN-28, SGC-790l and BGC-823 cancer cells. PMID: 24377515
12. It is a tumor suppressor gene which influences the proliferation and invasion of gastric cancer by regulating RAS/ERK signaling pathway. PMID: 24531877
13. Germline RASAL1 alterations are uncommon in patients with Cowden syndrome but may not be infrequent in patients with apparently sporadic follicular-variant papillary thyroid cancer. PMID: 24712574
14. We identified RASAL1 as a major tumor suppressor gene that is frequently inactivated by hypermethylation and mutations, providing a new alternative genetic background for thyroid cancer, particularly FTC and ATC. PMID: 24136889
15. Hypermethylations of RASAL1 and KLOTHO is associated with renal dysfunction in a Chinese population environmentally exposed to cadmium PMID: 23665422
16. decreased RASAL1 expression is a characteristic of gastric cancer and regulated by epigenetic mechanisms PMID: 22825043
17. Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes. PMID: 23251034
18. Reduced expression of RAS protein activator like-1 is associated with gastric cancer. PMID: 20473946
19. Galpha and Gbeta gamma require distinct Src-dependent pathways for its activation PMID: 12221082
20. RASAL preservs of Ca2+ frequency information PMID: 16009725
21. RASAL constitutes a tumor suppressor gene and therefore further emphasized the importance of Ca(2+) in the regulation of Ras signaling and has established that deregulation of this pathway is an important step in Ras-mediated tumorigenesis PMID: 17640920
22. Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression. PMID: 18992247

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HGNC: 9873

OMIM: 604118

KEGG: hsa:8437

STRING: 9606.ENSP00000450244

UniGene: Hs.528693