RASAL1 Antibody, Biotin conjugated

Code CSB-PA019351LD01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RASAL1 Polyclonal antibody
Uniprot No.
Target Names
RASAL1
Alternative Names
GAP1 like protein antibody; MRASAL antibody; RAS GTPase activating protein like antibody; RAS protein activator like 1 (GAP1 like) antibody; RAS protein activator like 1 antibody; RASAL antibody; Rasal1 antibody; rasGAP activating like protein 1 antibody; RasGAP-activating-like protein 1 antibody; RASGAP1 LIKE antibody; RASL1_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human RasGAP-activating-like protein 1 protein (698-804AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Biotin
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, pH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Probable inhibitory regulator of the Ras-cyclic AMP pathway. Plays a role in dendrite formation by melanocytes.
Gene References into Functions
  1. Domain topology of human Rasal PMID: 28885980
  2. HIF1alpha and transforming growth factor (TGF)/SMAD signalling pathways synergistically regulate hypoxia-induced endothelial-to-mesenchymal transition through both DNMT3a-mediated hypermethylation of RASAL1 promoter and direct SNAIL induction. PMID: 27012941
  3. RASAL1 role in in sorafenib-resistance of liver cancer cells PMID: 27878301
  4. our study showed significantly longer overall survival times for oesophagogastric adenocarcinoma patients without RASAL1 expression PMID: 28011578
  5. DNA methylation, TGFbeta1 and RASAL1 appear to have an interacting relationship. PMID: 27124111
  6. Report a new subtype of high-grade mandibular osteosarcoma with RASAL1/MDM2 amplification. PMID: 26997440
  7. These findings suggest that Ebp1 suppressed thyroid cancer cell lines by upregulating RASRAL expression. PMID: 26008146
  8. large chromosome 12 rearrangement, spanning MDM2 and RASAL1, is the first recurrent molecular abnormality to be reported in juvenile ossifying fibroma PMID: 24925056
  9. Loss of RASAL1 expression is associated with gastric carcinogenesis. PMID: 25735335
  10. Transcriptional suppression of RASAL1 through aberrant promoter methylation contributes to endothelial-mesenchymal transition and ultimately to progression of cardiac fibrosis. PMID: 25616414
  11. Promoter hypermethylation of the RASAL1 gene was detected in MKN-28, SGC-790l and BGC-823 cancer cells. PMID: 24377515
  12. It is a tumor suppressor gene which influences the proliferation and invasion of gastric cancer by regulating RAS/ERK signaling pathway. PMID: 24531877
  13. Germline RASAL1 alterations are uncommon in patients with Cowden syndrome but may not be infrequent in patients with apparently sporadic follicular-variant papillary thyroid cancer. PMID: 24712574
  14. We identified RASAL1 as a major tumor suppressor gene that is frequently inactivated by hypermethylation and mutations, providing a new alternative genetic background for thyroid cancer, particularly FTC and ATC. PMID: 24136889
  15. Hypermethylations of RASAL1 and KLOTHO is associated with renal dysfunction in a Chinese population environmentally exposed to cadmium PMID: 23665422
  16. decreased RASAL1 expression is a characteristic of gastric cancer and regulated by epigenetic mechanisms PMID: 22825043
  17. Ras GTPase activating (RasGAP) activity of the dual specificity GAP protein Rasal requires colocalization and C2 domain binding to lipid membranes. PMID: 23251034
  18. Reduced expression of RAS protein activator like-1 is associated with gastric cancer. PMID: 20473946
  19. Galpha and Gbeta gamma require distinct Src-dependent pathways for its activation PMID: 12221082
  20. RASAL preservs of Ca2+ frequency information PMID: 16009725
  21. RASAL constitutes a tumor suppressor gene and therefore further emphasized the importance of Ca(2+) in the regulation of Ras signaling and has established that deregulation of this pathway is an important step in Ras-mediated tumorigenesis PMID: 17640920
  22. Decreased expression of the RAS-GTPase activating protein RASAL1 is associated with colorectal tumor progression. PMID: 18992247

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Tissue Specificity
Highly expressed in thyroid and adrenal medulla, lower expression in brain, spinal cord and trachea. Expressed in melanocytes.
Database Links

HGNC: 9873

OMIM: 604118

KEGG: hsa:8437

STRING: 9606.ENSP00000450244

UniGene: Hs.528693

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