RASGEF1B Antibody, HRP conjugated

Code CSB-PA610807LB01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RASGEF1B Polyclonal antibody
Uniprot No.
Target Names
RASGEF1B
Alternative Names
FLJ31695 antibody; GPI gamma-4 antibody; GPIG4 antibody; MGC46251 antibody; Ras-GEF domain-containing family member 1B antibody; RasGEF domain family member 1B antibody; RASGEF1B antibody; RGF1B_HUMAN antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Ras-GEF domain-containing family member 1B protein (1-300AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
HRP
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Guanine nucleotide exchange factor (GEF) with specificity for RAP2A, it doesn't seems to activate other Ras family proteins (in vitro).
Gene References into Functions
  1. We show that knockdown of the expression of mcircRasGEF1B reduces LPS-induced ICAM-1 expression. Additionally, we demonstrate that mcircRasGEF1B regulates the stability of mature ICAM-1 mRNAs. PMID: 27362560
  2. As an addition to PRKG2 and RASGEFIB genes, we propose to include BMP3 gene as the principal determinant of the observed common phenotype. PMID: 22303795
  3. Mutation of the Ser39 in Rap1 changed the specificity and allowed the nucleotide exchange of Rap1(S39F) to be stimulated by RasGEF1B PMID: 19645719
Subcellular Location
Early endosome. Late endosome. Midbody.
Database Links

HGNC: 24881

OMIM: 614532

KEGG: hsa:153020

STRING: 9606.ENSP00000264400

UniGene: Hs.591696

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