RBSN Antibody

Code CSB-PA884441LA01HU
Size US$166
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Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RBSN Polyclonal antibody
Uniprot No.
Target Names
RBSN
Alternative Names
110 kDa protein antibody; FYVE finger containing Rab5 effector protein Rabenosyn 5 antibody; FYVE finger-containing Rab5 effector protein rabenosyn-5 antibody; Rabenosyn-5 antibody; RBNS5_HUMAN antibody; Zfyve20 antibody; zinc finger FYVE domain containing 20 antibody; Zinc finger FYVE domain-containing protein 20 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human Rabenosyn-5 protein (201-500AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated

The RBSN Antibody (Product code: CSB-PA884441LA01HU) is Non-conjugated. For RBSN Antibody with conjugates, please check the following table.

Available Conjugates
Conjugate Product Code Product Name Application
HRP CSB-PA884441LB01HU RBSN Antibody, HRP conjugated ELISA
FITC CSB-PA884441LC01HU RBSN Antibody, FITC conjugated
Biotin CSB-PA884441LD01HU RBSN Antibody, Biotin conjugated ELISA
Clonality
Polyclonal
Isotype
IgG
Purification Method
>95%, Protein G purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
Preservative: 0.03% Proclin 300
Constituents: 50% Glycerol, 0.01M PBS, PH 7.4
Form
Liquid
Tested Applications
ELISA
Protocols
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

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Target Background

Function
Rab4/Rab5 effector protein acting in early endocytic membrane fusion and membrane trafficking of recycling endosomes. Required for endosome fusion either homotypically or with clathrin coated vesicles. Plays a role in the lysosomal trafficking of CTSD/cathepsin D from the Golgi to lysosomes. Also promotes the recycling of transferrin directly from early endosomes to the plasma membrane. Binds phospholipid vesicles containing phosphatidylinositol 3-phosphate (PtdInsP3). Plays a role in the recycling of transferrin receptor to the plasma membrane.
Gene References into Functions
  1. A functional defect in the endocytic pathway resulting from a point mutation in Rabenosyn-5 leads to severe multi-organ disorder. PMID: 25233840
  2. transferrin receptors are delivered selectively from clathrin-coated pits on the plasma membrane into a specific subpopulation of endosomes enriched in the multivalent Rab GTPase and phosphoinositide-binding protein Rabenosyn-5. PMID: 22308388
  3. Data implicate hVps45 and Rabenosyn-5 in post early endosome transport, and suggest that their interaction serves as a nexus to promote bidirectional transport along the endosome-to-recycling compartment and endosome-to-Golgi axes. PMID: 19931244
  4. results demonstrate that even the structurally similar effector domains in rabenosyn-5 can achieve highly selective recognition of distinct subsets of Rab GTPases exclusively through interactions with the switch and interswitch regions PMID: 16034420
Subcellular Location
Cell membrane; Lipid-anchor; Cytoplasmic side. Early endosome membrane; Lipid-anchor.
Database Links

HGNC: 20759

OMIM: 609511

KEGG: hsa:64145

STRING: 9606.ENSP00000253699

UniGene: Hs.475565

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