RDH5 Antibody

Code CSB-PA856423ESR1HU
Size US$166
Order now
Image
  • Immunohistochemistry of paraffin-embedded human testis tissue using CSB-PA856423ESR1HU at dilution of 1:100

  • Immunohistochemistry of paraffin-embedded human colon tissue using CSB-PA856423ESR1HU at dilution of 1:100

Have Questions? Leave a Message or Start an on-line Chat

Product Details

Full Product Name
Rabbit anti-Homo sapiens (Human) RDH5 Polyclonal antibody
Uniprot No.
Target Names
RDH5
Alternative Names
RDH5 antibody; HSD17B9 antibody; RDH1 antibody; SDR9C5 antibody; Retinol dehydrogenase 5 antibody; EC 1.1.1.209 antibody; EC 1.1.1.315 antibody; EC 1.1.1.53 antibody; 11-cis retinol dehydrogenase antibody; 11-cis RDH antibody; 11-cis RoDH antibody; 9-cis retinol dehydrogenase antibody; 9cRDH antibody; Short chain dehydrogenase/reductase family 9C member 5 antibody
Raised in
Rabbit
Species Reactivity
Human
Immunogen
Recombinant Human 11-cis retinol dehydrogenase protein (24-318AA)
Immunogen Species
Homo sapiens (Human)
Conjugate
Non-conjugated
Clonality
Polyclonal
Isotype
IgG
Purification Method
Antigen Affinity Purified
Concentration
It differs from different batches. Please contact us to confirm it.
Buffer
PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Form
Liquid
Tested Applications
ELISA, IHC
Recommended Dilution
Application Recommended Dilution
IHC 1:20-1:200
Troubleshooting and FAQs
Storage
Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Lead Time
Basically, we can dispatch the products out in 1-3 working days after receiving your orders. Delivery time maybe differs from different purchasing way or location, please kindly consult your local distributors for specific delivery time.

Customer Reviews and Q&A

 Customer Reviews

There are currently no reviews for this product.

Submit a Review here

Target Background

Function
Catalyzes the oxidation of cis-isomers of retinol, including 11-cis-, 9-cis-, and 13-cis-retinol in an NAD-dependent manner. Has no activity towards all-trans retinal. Plays a significant role in 11-cis retinol oxidation in the retinal pigment epithelium cells (RPE). Also recognizes steroids (androsterone, androstanediol) as its substrates.
Gene References into Functions
  1. a novel homozygous missense mutation, (c.602 C > T) in exon 4 of the RDH5 gene (MIM: 601617) was identified. This mutation resulted in substitution of phenyl alanine for serine at amino acid 201 (p.Ser201Phe) of the RDH5 gene. Identification of this mutation reveals the allelic heterogeneity of RDH5 in patients with retinitis pigmentosa phenotype. PMID: 29892959
  2. We conclude that the expression of Rlbp1 and Rdh5 critically depends on functional Mitf in the RPE and suggest that MITF has an important role in controlling retinoid processing in the RPE. PMID: 26876013
  3. A novel c.832C>T (p.Arg278Ter) nonsense mutation in RDH5 was identified. Preserved rod function was observed in one young subject in this study. PMID: 25170858
  4. Macular cone density is lower and the regularity of the macular cone mosaic spatial arrangement is disrupted in eyes with fundus albipunctatus. PMID: 24246574
  5. RDH5 sequence analysis revealed a novel five base pair deletion, c.913_917delGTGCT (p.Val305Hisfs*29), in family A, and a novel missense mutation, c.758T>G (p.Met253Arg), in family B with fundus albipunctatus. PMID: 22736946
  6. Four novel RDH5 gene mutations were identified in fundus albipunctatus Israeli patients. Of them, the null mutations c.343C>T (p.R54X) and c. 242delTGCC were the most prevalent. PMID: 22815624
  7. The proband had a compound heterozygotic missense mutation of Cys59Ser (TGC --> AGC) and a nonsense mutation of Trp95ter (TGG --> TGA) in the RDH5 gene. PMID: 22669287
  8. The clinical and electrophysiologic phenotype of patients with RDH5 retinopathy is variable. PMID: 21529959
  9. Mutations in RDH5 associated with fundus albipunctatus seem to prevent normal lipofuscin accumulation. PMID: 20829743
  10. An amino acid important for steroid/retinoid discrimination was identified and its significance was highlighted by the results of molecular modeling studies. PMID: 20382160
  11. Macular dystrophy is caused by the RDH5 mutation as a phenotype variation in fundus albipunctus. PMID: 11812441
  12. Macular dystrophy is caused by the RDH5 gene mutation as a phenotype variation in fundus albipunctatus. PMID: 12788147
  13. Fundus changes due to Fundus albipunctatus associated with mutations in the RDH5 gene. PMID: 12860821
  14. RDH5 gene mutations cause a progressive cone dystrophy or macular dystrophy as well as night blindness. The clinical phenotype including electrophysiological responses varied among patients with the RDH5 gene mutations. PMID: 12906118
  15. A homozygous G490T (Val164Phe) missense RDH5 gene mutation was detected. PMID: 12967826
  16. Homozygous Gly107Arg mutation in the RDH5 gene in two unrelated Japanese families with fundus albipunctatus. PMID: 15007239
  17. Cone dystrophy can be present in patients with fundus albipunctatus, not only elderly men but also young women. PMID: 15302662
  18. Our study indicates that different mutations in the RDH5 gene can cause phenotypic variations of either fundus albipunctatus or familial fleck retina with night blindness. PMID: 16637847
  19. study describes an unusual family which included a mother with fundus albipunctatus and three children with typical retinitis pigmentosa; a novel RDH5 mutation was found PMID: 18363170

Show More

Hide All

Involvement in disease
Fundus albipunctatus (FALBI)
Subcellular Location
Endoplasmic reticulum membrane; Multi-pass membrane protein; Lumenal side.
Protein Families
Short-chain dehydrogenases/reductases (SDR) family
Tissue Specificity
Widely expressed. In the eye, abundant in the retinal pigment epithelium.
Database Links

HGNC: 9940

OMIM: 136880

KEGG: hsa:5959

STRING: 9606.ENSP00000257895

UniGene: Hs.600940

icon of phone
Call us
301-363-4651 (Available 9 a.m. to 5 p.m. CST from Monday to Friday)
icon of address
Address
7505 Fannin St., Ste 610, Room 7 (CUBIO Innovation Center), Houston, TX 77054, USA
icon of social media
Join us with

Subscribe newsletter

Leave a message

* To protect against spam, please pass the CAPTCHA test below.
CAPTCHA verification
© 2007-2024 CUSABIO TECHNOLOGY LLC All rights reserved. 鄂ICP备15011166号-1
webinars: DT3C facilitates antibody internalization X
Place an order now

I. Product details

*
*
*
*

II. Contact details

*
*

III. Ship To

*
*
*
*
*
*
*

IV. Bill To

*
*
*
*
*
*
*
*